Phenotypes Associated with This Genotype

Genotype
MGI:3513849

• Allelic Composition: Apc^tm1Cip/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94108 )

• heterozygotes begin to die at 4 months of age with 50% dying by 6 months of age

neoplasm

increased intestinal adenocarcinoma incidence ( J:94108 )

• in situ carcinomas are seen in both the small and large intestines

• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas

increased intestinal adenoma incidence ( J:94108 )

• small and large adenomas are seen throughout the intestine

• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions

increased colon adenoma incidence ( J:94108 )

• compared to Apc^Min heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

cardiovascular system

rectal hemorrhage ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

digestive/alimentary system

rectal hemorrhage ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

rectal prolapse ( J:94108 )

• rectal prolapse, associated with more severe polyposis in the colon, is seen as early as 4 months of age and is seen in 61% of surviving mutants by 6 months of age

• the prolapse is highly dysplatic and in 10% of these dysplatic areas adenocarcinoma is also seen

• fewer mutants raised in specific pathogen-free conditions developed rectal prolapse

increased intestinal adenocarcinoma incidence ( J:94108 )

• in situ carcinomas are seen in both the small and large intestines

• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas

increased intestinal adenoma incidence ( J:94108 )

• small and large adenomas are seen throughout the intestine

• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions

increased colon adenoma incidence ( J:94108 )

• compared to Apc^Min heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines

hematopoietic system

anemia ( J:94108 )

• first seen around 4 months of age, associated with decreased life span

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

integument

increased mammary adenocarcinoma incidence ( J:94108 )

• 9% of heterozygotes developed mammary adenocanthomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:94108
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:94108