Phenotypes Associated with This Genotype

Genotype
MGI:4838642

• Allelic Composition: Sav1^tm1.1Dupa/Sav1^tm1.1Dupa; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:165471 )

• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice

abnormal large intestine crypts of Lieberkuhn morphology ( J:165471 )

• enlarged in the colon

abnormal small intestine crypts of Lieberkuhn morphology ( J:165471 )

• enlarged

colon polyps ( J:165471 )

• by 13 months of age, all male mice develop colonic polyps with 'saw-tooth' appearance characteristic of sessile serrated polyps unlike wild-type mice

• 3 months after DSS treatment, mice develop colonic polyps unlike similarly treated wild-type mice and well before homozygous mice not treated with DSS

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:165471 )

• enlarged in the colon

abnormal small intestine crypts of Lieberkuhn morphology ( J:165471 )

• enlarged

cellular

abnormal enterocyte proliferation ( J:165471 )

• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colonic disease		DOID:5353		J:165471