Sav1^tm1.1Dupa
Targeted Allele Detail

Summary

• Symbol: Sav1^tm1.1Dupa
• Name: salvador family WW domain containing 1; targeted mutation 1.1, Duojia Pan
• MGI ID: MGI:4838640
• Synonyms: Sav1^flox
• Gene: Sav1 Location: Chr12:70011786-70033776 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Sav1^tm1.1Dupa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165471
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:165471)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sav1 Mutation: 19 strains or lines available

References

• Original: J:165471 Cai J, et al., The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 2010 Nov 1;24(21):2383-8
• All: 6 reference(s)