About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sav1tm1.1Dupa
targeted mutation 1.1, Duojia Pan
MGI:4838640
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sav1tm1.1Dupa/Sav1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838642
cn2
 		Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838644


Genotype
MGI:4838642
cn1
Allelic
Composition		 Sav1tm1.1Dupa/Sav1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Dupa mutation (1 available); any Sav1 mutation (20 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte proliferation ( J:165471 )
• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice
colon polyps ( J:165471 )
• by 13 months of age, all male mice develop colonic polyps with 'saw-tooth' appearance characteristic of sessile serrated polyps unlike wild-type mice
• 3 months after DSS treatment, mice develop colonic polyps unlike similarly treated wild-type mice and well before homozygous mice not treated with DSS

endocrine/exocrine glands

cellular
abnormal enterocyte proliferation ( J:165471 )
• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colonic disease DOID:5353 J:165471




Genotype
MGI:4838644
cn2
Allelic
Composition		 Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Dupa mutation (1 available); any Sav1 mutation (20 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:165471 )
N
• mice exhibit normal cell proliferation in the small intestine and colon
• mice, whether treated with DSS or not, do not develop colonic polyps




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory