Yap1^tm1.1Dupa
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1.1Dupa
• Name: yes-associated protein 1; targeted mutation 1.1, Duojia Pan
• MGI ID: MGI:4819826
• Synonyms: Yap^flox
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1.1Dupa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162628
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exons 1 and 2 floxed. (J:162628)

Expression

In Mice Carrying this Mutation:	76 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Yap1^tm1.1Dupa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 37 strains or lines available

References

• Original: J:162628 Zhang N, et al., The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell. 2010 Jul 20;19(1):27-38
• All: 83 reference(s)