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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yap1tm1.1Dupa
targeted mutation 1.1, Duojia Pan
MGI:4819826
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Yap1em1Jfm/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S1 * C57BL/6 * FVB MGI:8310080
cn2
 		Krastm4Tyj/Krastm4Tyj
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA MGI:4819844
cn3
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas MGI:5660349
cn4
 		Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:4819843
cn5
 		Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:4819842
cn6
 		Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:4819841
cn7
 		Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838644
cn8
 		Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838643


Genotype
MGI:8310080
cn1
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Yap1em1Jfm/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S1 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Yap1em1Jfm mutation (0 available); any Yap1 mutation (40 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to myocardial ischemic injury ( J:381052 )
• better functional recovery 8 weeks after coronary-artery-occlusion-induced MI
decreased myocardial infarct size ( J:381052 )
• less fibrosis in scar 8 weeks after coronary-artery-occlusion-induced MI

homeostasis/metabolism
decreased susceptibility to myocardial ischemic injury ( J:381052 )
• better functional recovery 8 weeks after coronary-artery-occlusion-induced MI
decreased myocardial infarct size ( J:381052 )
• less fibrosis in scar 8 weeks after coronary-artery-occlusion-induced MI




Genotype
MGI:4819844
cn2
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (68 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm

liver/biliary system




Genotype
MGI:5660349
cn3
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (55 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (45 available)
Wwtr1tm1.2Eno mutation (0 available); any Wwtr1 mutation (24 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj

growth/size/body
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj




Genotype
MGI:4819843
cn4
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:162628 )
N
• mice do not exhibit bile duct proliferation
enlarged liver ( J:162628 )
• slightly

neoplasm
neoplasm ( J:162628 )
N
• mice do not develop bile duct hamartomas or hepatocellular carcinoma

growth/size/body
enlarged liver ( J:162628 )
• slightly




Genotype
MGI:4819842
cn5
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:162628 )
N
• liver is as enlarge as in Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice
• bile over-proliferation observed in Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice is suppressed

neoplasm
neoplasm ( J:162628 )
N
• mice do not develop bile duct hamartomas or hepatocellular carcinoma unlike Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice




Genotype
MGI:4819841
cn6
Allelic
Composition		 Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged liver ( J:162628 )

liver/biliary system
increased hepatocyte apoptosis ( J:162628 )
• at 1 to 2 months
abnormal bile duct morphology ( J:162628 )
• after 30 weeks, mice lack bile ducts or bile duct-like structures unlike wild-type mice
abnormal bile duct development ( J:162628 )
• livers fail to form mature bile ducts unlike in wild-type mice
abnormal hepatocyte morphology ( J:162628 )
• at 1 to 2 months, the liver contains multiple areas of injured hepatocytes unlike in wild-type mice
liver fibrosis ( J:162628 )
• mice exhibit progressive liver fibrosis with early periportal fibrosis at 20 weeks unlike wild-type mice
• at 30 weeks, mice exhibit advanced fibrosis with cirrhosis unlike wild-type mice

homeostasis/metabolism

endocrine/exocrine glands
abnormal bile duct morphology ( J:162628 )
• after 30 weeks, mice lack bile ducts or bile duct-like structures unlike wild-type mice
abnormal bile duct development ( J:162628 )
• livers fail to form mature bile ducts unlike in wild-type mice

cellular
increased hepatocyte apoptosis ( J:162628 )
• at 1 to 2 months




Genotype
MGI:4838644
cn7
Allelic
Composition		 Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Dupa mutation (1 available); any Sav1 mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:165471 )
N
• mice exhibit normal cell proliferation in the small intestine and colon
• mice, whether treated with DSS or not, do not develop colonic polyps




Genotype
MGI:4838643
cn8
Allelic
Composition		 Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
digestive/alimentary phenotype ( J:165471 )
N
• mice, whether treated with DSS or not, do not develop colonic polyps
increased enterocyte apoptosis ( J:165471 )
• in DSS-treated mice
abnormal enterocyte proliferation ( J:165471 )
• DSS-treated mice exhibit decreased cell proliferation in the colon compared with similarly treated wild-type mice
increased susceptibility to induced colitis ( J:165471 )
• DSS-treated mice exhibit increased mortality a rapid decrease in body weight, increased apoptotic cells in the colon, and decreased proliferating cells in the colon compared with similarly treated wild-type mice

immune system
increased susceptibility to induced colitis ( J:165471 )
• DSS-treated mice exhibit increased mortality a rapid decrease in body weight, increased apoptotic cells in the colon, and decreased proliferating cells in the colon compared with similarly treated wild-type mice

homeostasis/metabolism

growth/size/body
increased susceptibility to weight loss ( J:165471 )
• in DSS-treated mice

cellular
increased enterocyte apoptosis ( J:165471 )
• in DSS-treated mice
abnormal enterocyte proliferation ( J:165471 )
• DSS-treated mice exhibit decreased cell proliferation in the colon compared with similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory