Yap1^em1Jfm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Yap1^em1Jfm
• Name: yes-associated protein 1; endonuclease-mediated mutation 1, James F Martin
• MGI ID: MGI:8310071
• Synonyms: Yap^K265R
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^em1Jfm page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Lysine codon 265 (AAG) was changed to arginine (GCG) (p.K265R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. In the encoded protein, the mutation blocks acetylation of the affected residue, which enhances its nuclear localization and promotes cardiac regeneration. (J:381052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 40 strains or lines available

References

• Original: J:381052 Liu S, et al., Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025 Jan 7;151(1):59-75
• All: 1 reference(s)