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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yap1em1Jfm
endonuclease-mediated mutation 1, James F Martin
MGI:8310071
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Yap1em1Jfm/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S1 * C57BL/6 * FVB MGI:8310080


Genotype
MGI:8310080
cn1
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Yap1em1Jfm/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S1 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Yap1em1Jfm mutation (0 available); any Yap1 mutation (40 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to myocardial ischemic injury ( J:381052 )
• better functional recovery 8 weeks after coronary-artery-occlusion-induced MI
decreased myocardial infarct size ( J:381052 )
• less fibrosis in scar 8 weeks after coronary-artery-occlusion-induced MI

homeostasis/metabolism
decreased susceptibility to myocardial ischemic injury ( J:381052 )
• better functional recovery 8 weeks after coronary-artery-occlusion-induced MI
decreased myocardial infarct size ( J:381052 )
• less fibrosis in scar 8 weeks after coronary-artery-occlusion-induced MI




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory