Lats2^tm1.1Dupa
Targeted Allele Detail

Summary

• Symbol: Lats2^tm1.1Dupa
• Name: large tumor suppressor 2; targeted mutation 1.1, Duojia Pan
• MGI ID: MGI:5648494
• Synonyms: Lats2^flox
• Gene: Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
• Alliance: Lats2^tm1.1Dupa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223215
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was placed in intron 4 and an FRT-neomycin-FRT-loxP cassette was introduced to intron 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats2 Mutation: 42 strains or lines available

References

• Original: J:223215 Chen Q, et al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015 Jun 15;29(12):1285-97
• All: 2 reference(s)