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Targeted Allele Detail
Symbol: Apctm1Rak
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:1857951
Synonyms: APC1638, Apc1638N, APC1638N
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: Apctm1Rak page
Microadenoma in Mbd4tm1Wed/Mbd4tm1Wed Apctm1Rak/Apc+ gastrointestinal tract

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:20443
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 15 at a site corresponding to codon 1638. This mutation is predicted to result in a truncated protein. RT-PCR analysis detected a mutated transcript produced from this allele, but a truncated protein was not consistently detected by Western blot analysis. (J:20443)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Apctm1Rak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  116 strains or lines available
Original:  J:20443 Fodde R, et al., A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73
All:  107 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory