Tg(Vil1-cre/ERT2)23Syr
Transgene Detail

Summary

• Symbol: Tg(Vil1-cre/ERT2)23Syr
• Name: transgene insertion 23, Sylvie Robine
• MGI ID: MGI:3053826
• Synonyms: TgvCre^ERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, vil-Cre-ER^T2, villin-creERT2, villin::CreER^T2, Villin-Cre^(ER-T2), Villin-CreER^T2
• Transgene: Tg(Vil1-cre/ERT2)23Syr Location: unknown
• Alliance: Tg(Vil1-cre/ERT2)23Syr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Mutation details: A 9 kb segment of the regulatory region of the mouse Vil gene drives expression of cre recombinase fused to a mutated ligand-binding domain of the human estrogen receptor. Cre recombination is inducible with tamoxifen treatment in epithelial cells all along the crypt-villus axis and in undifferentiated progenitor cells in the crypt region. This is a representative record for the two lines generated (Fo23 and Fo24) that have the same inducible expression pattern. Only 1 copy of the transgene is integrated into these lines. (J:92295)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vil1 (mouse) Summary of all recombinase alleles driven by Vil1. Comparative matrix view of recombinase activities Alliance mouse Vil1 gene page

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structures

Tumor Data

List all tumor models in MMHCdb carrying Tg(Vil1-cre/ERT2)23Syr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:92295 el Marjou F, et al., Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 2004 Jul;39(3):186-93
• All: 383 reference(s)