Phenotypes Associated with This Genotype

Genotype
MGI:5688288

• Allelic Composition: Apc^M1Tno/Apc⁺
• Genetic Background: either: B6JJcl.B6(D2JJcl)-Apc^M1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:218227 )

• 100% of females but only 10.1% of males develop breast cancers

• breast cancers arise from 2 months of age

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

increased skin tumor incidence ( J:218227 )

• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors

• trichogenic tumors in males arise from 9 months of age

increased pilomatricoma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased trichoepithelioma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased osteosarcoma incidence ( J:218227 )

• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas

increased osteoma incidence ( J:218227 )

• 54.2% of females and 93.3% of males exhibit osteomas

• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas

• osteomas in males arise from 9 months of age

mortality/aging

premature death ( J:218227 )

• females become moribund as early as 9 weeks of age

integument

increased mammary gland tumor incidence ( J:218227 )

• 100% of females but only 10.1% of males develop breast cancers

• breast cancers arise from 2 months of age

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

increased skin tumor incidence ( J:218227 )

• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors

• trichogenic tumors in males arise from 9 months of age

increased pilomatricoma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

increased trichoepithelioma incidence ( J:218227 )

• trichogenic tumors are trichoepithelioma and pilomatricoma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:218227 )

• 100% of females but only 10.1% of males develop breast cancers

• breast cancers arise from 2 months of age

increased mammary adenocarcinoma incidence ( J:218227 )

• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

skeleton

increased osteosarcoma incidence ( J:218227 )

• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas

increased osteoma incidence ( J:218227 )

• osteomas in males arise from 9 months of age

• 54.2% of females and 93.3% of males exhibit osteomas

• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:218227