Phenotypes Associated with This Genotype

Genotype
MGI:2175903

• Allelic Composition: Apc^Min/Apc⁺
• Genetic Background: involves: AKR/J * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenocarcinoma incidence ( J:10209 )

• locally invasive tumors seen in older animals but no metastasis

• sometimes small areas of carcinomas in anemic animals only

• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age

increased intestinal adenoma incidence ( J:10209 )

• visible tumors of the large and small intestine

• either polyploid, papillary or sessile adenomas

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:10209 )

• locally invasive tumors seen in older animals but no metastasis

• sometimes small areas of carcinomas in anemic animals only

• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age

increased intestinal adenoma incidence ( J:10209 )

• visible tumors of the large and small intestine

• either polyploid, papillary or sessile adenomas

melena ( J:10209 )

• bloody feces

hematopoietic system

anemia ( J:10209 )

• progressive adult onset anemia beconming severe and chronic

• diagnosed in mutant mice by 60 days of age

• with few exceptions, likely the cause of lethality by 120 days of age

decreased hematocrit ( J:10209 )

• moribund animals with hematocrits around 10-20%

homeostasis/metabolism

hyperlipidemia ( J:10209 )

mortality/aging

premature death ( J:10209 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:830