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Chemically induced Allele Detail
Symbol: ApcMin
Name: APC, WNT signaling pathway regulator; multiple intestinal neoplasia
MGI ID: MGI:1856318
Synonyms: Apc-, Apc580S, Apcdelta850, ApcΔ850, Min, Min-
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: ApcMin page
Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice

Show the 5 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA transversion point mutation that alters nucleotide 2549 from a T to an A (mRNA: NM_001360980.1; protein: NM_007462.3). This converts codon 850 from one encoding a leucine to a stop codon (p.Leu850*), truncating the expected polypeptide. (J:830)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 20 assay results
5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 27 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying ApcMin
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  154 strains or lines available
Original:  J:10209 Moser AR, et al., A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science. 1990 Jan 19;247(4940):322-4
All:  1072 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory