Phenotypes Associated with This Genotype

Genotype
MGI:5558947

• Allelic Composition: Tnf^tm2.1Gkl/Tnf^tm2.1Gkl; Tg(Fabp1-cre)1Jig/0
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:204557 )

• disruption of the mucosal architecture with prominent villous distortion characterized by widening and decreased number of villi

• increase in numbers of activated CD4+ cells within their intestinal mucosa

abnormal small intestinal villus morphology ( J:204557 )

• prominent villous distortion characterized by widening and decreased number of villi

decreased small intestinal villus number ( J:204557 )

large intestinal inflammation ( J:204557 )

• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon

small intestinal inflammation ( J:204557 )

• chronic small intestinal inflammation

ileum inflammation ( J:204557 )

• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells

• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

immune system

large intestinal inflammation ( J:204557 )

• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon

small intestinal inflammation ( J:204557 )

• chronic small intestinal inflammation

ileum inflammation ( J:204557 )

• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells

• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

increased circulating tumor necrosis factor level ( J:204557 )

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:204557 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:204557