Phenotypes Associated with This Genotype

Genotype
MGI:4820806

• Allelic Composition: Ret^tm1Cos/Ret^tm1Cos
• Genetic Background: involves: 129S/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal enteric nervous system morphology ( J:135153 )

• absence of neurofilament labeling in latissimus dorsi muscle of P0 mice

abnormal enteric ganglia morphology ( J:135153 )

• display a nearly complete absence of the enteric ganglia throughout the entire gastrointestinal tract

renal/urinary system

absent kidney ( J:135153 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Hirschsprung's disease		DOID:10487	OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644	J:135153