Phenotypes Associated with This Genotype

Genotype
MGI:5636659

• Allelic Composition: Apc^Min/Apc⁺; Msh2^tm1Mak/Msh2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75393 )

• mice become moribound and die from anemia and intestinal obstruction at a mean age of 82 days

neoplasm

increased intestinal adenoma incidence ( J:75393 )

• mice exhibit accelerated intestinal tumorigenesis compared to single Apc^Min heterozygous mice, with a large increase in number of small and large bowel adenomas that develop

• an average of 333 adenomas are seen in 10 mutants at 47-78 days of age compared to a mean of 48 adenomas in single Apc^Min heterozygotes

digestive/alimentary system

intestine polyps ( J:200824 )

increased intestinal adenoma incidence ( J:75393 )

• mice exhibit accelerated intestinal tumorigenesis compared to single Apc^Min heterozygous mice, with a large increase in number of small and large bowel adenomas that develop

• an average of 333 adenomas are seen in 10 mutants at 47-78 days of age compared to a mean of 48 adenomas in single Apc^Min heterozygotes

intestinal obstruction ( J:75393 )

• due to tumors

hematopoietic system

anemia ( J:75393 )

• mutants exhibit enhanced polyp formation in the small intestine and colon at 6 weeks of age compared to double heterozygous mice

• treatment with the Nos2 (iNOS) inhibitor L-NIL has no effect on polyp number

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:75393 , J:200824