Pikfyve^tm2.1Tssk
Targeted Allele Detail

Summary

• Symbol: Pikfyve^tm2.1Tssk
• Name: phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 2.1, Takehiko Sasaki
• MGI ID: MGI:5474981
• Synonyms: PIKfyve^Flox, PipkIII^flox
• Gene: Pikfyve Location: Chr1:65225842-65317854 bp, + strand Genetic Position: Chr1, 32.94 cM, cytoband C3
• Alliance: Pikfyve^tm2.1Tssk page

Hair greying in tamoxifen-treated Pikfyve^tm2.1Tssk/Pikfyve^tm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193689
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked selection cassette and loxP site were inserted into intron 37 and a loxP site was inserted into intron 38 via homologous recombination. Flp mediated recombination removed the selection cassette, leaving exon 38 floxed. (J:193689)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pikfyve Mutation: 114 strains or lines available

References

• Original: J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
• All: 2 reference(s)