Phenotypes Associated with This Genotype

Genotype
MGI:3814722

• Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:131037 )

• animals are smaller than controls

neoplasm

increased squamous cell carcinoma incidence ( J:131037 )

• some mice develop SCC (spontaneously) by 40 weeks of age (>20%)

• all DMBA-treated mutant mice develop invasive skin cancers determined to be SCC with an average latency of 8 weeks, whereas no DMBA-treated controls develop cancer

vision/eye

cornea opacity ( J:131037 )

• due to hyperkeratinization of corneal epithelium

integument

delayed hair appearance ( J:131037 )

• mice show delayed hair growth

sparse hair ( J:131037 )

• adult hair is less dense than in controls

waved hair ( J:131037 )

• adult hair is wavy

abnormal hair shaft morphology ( J:131037 )

• hair shaft diameter is reduced relative to controls

abnormal hair follicle morphology ( J:131037 )

• mild follicular plugging (keratinous debris filling follicular openings) is observed

reddish skin ( J:131037 )

• increased relative to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:131037