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Phenotypes Associated with This Genotype
Genotype
MGI:2652741
Allelic
Composition		 Gpx1tm1Ysh/Gpx1+
Gpx2tm2Coh/Gpx2tm2Coh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1tm1Ysh mutation (2 available); any Gpx1 mutation (24 available)
Gpx2tm2Coh mutation (0 available); any Gpx2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:71506 )
• 10% mortality before 35 days of age, however do not exhibit cachexia

digestive/alimentary system
perianal ulcer ( J:71506 )
• seen in 17% of mice
diarrhea ( J:71506 )
• seen in 17% of mice
intestinal inflammation ( J:71506 )
• seen in 50% of mice

immune system
intestinal inflammation ( J:71506 )
• seen in 50% of mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease DOID:0050589 OMIM:PS266600
 J:71506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory