Muc2^eey
Chemically induced Allele Detail

Summary

• Symbol: Muc2^eey
• Name: mucin 2; eeyore
• MGI ID: MGI:5471473
• Gene: Muc2 Location: Chr7:141276583-141308428 bp, + strand Genetic Position: Chr7, 87.1 cM, cytoband F5
• Alliance: Muc2^eey page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to C transition (T2996C, GenBank accession no. AJ511873) that results in the amino acid substitution of proline for serine in the C-terminal D4 domain. (J:194148)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc2 Mutation: 81 strains or lines available

References

• Original: J:194148 Heazlewood CK, et al., Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008 Mar 4;5(3):e54
• All: 1 reference(s)