Stat3^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Flv
• Name: signal transducer and activator of transcription 3; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2451328
• Synonyms: STAT3^f, STAT3KO
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Flv page

Crohn's disease-like pathogenesis in Stat3^tm1Flv/Stat3^tm1Flv Tg(Tek-cre)12Flv/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 18 through 20 were flanked by single loxP sites in introns 17 and 20. The floxed exons encode the Src homology 2 domain. (J:81973)

Disease models

Expression

In Mice Carrying this Mutation:	100 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:81973 Welte T, et al., STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84
• All: 31 reference(s)