Tg(Tek-cre)12Flv
Transgene Detail

Summary

• Symbol: Tg(Tek-cre)12Flv
• Name: transgene insertion 12, Richard A Flavell
• MGI ID: MGI:2136412
• Synonyms: btie2-cre, Cre^Tek, Tek-Cre, Tet-cre, Tie2^-Cre, Tie2-Cre, TIE2/cre, TIE2Cre, TIE2Cre⁺, Tie2(Tek)-Cre
• Transgene: Tg(Tek-cre)12Flv Location: Chr13:68608050-68849395 bp Genetic Position: Chr13, Syntenic
• Alliance: Tg(Tek-cre)12Flv page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Null/knockout, Recombinase)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Mutation details: Cre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. The transgene integrated into chromosome 13 causing a 241.3 Kb deletion and disrupting the following genes: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase), Fastkd3 (FAST kinase domains 3), 1700001L19Rik, Adcy2 (adenylate cyclase 2). The deletion results in a functional knock-out of Mtrr, Adcy2 and Fastkd3 in homozygous mice. Founder line 12 has a copy number of greater than 10. (J:68147, J:138838)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Disease models

Expression

In Mice Carrying this Mutation:

83 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
• All: 362 reference(s)