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Tg(Tek-cre)12Flv
Transgene Detail
Summary
Symbol: Tg(Tek-cre)12Flv
Name: transgene insertion 12, Richard A Flavell
MGI ID: MGI:2136412
Synonyms: btie2-cre, CreTek, Tek-Cre, Tet-cre, Tie2-Cre, Tie2-Cre, TIE2/cre, TIE2Cre, TIE2Cre+, Tie2(Tek)-Cre
Transgene: Tg(Tek-cre)12Flv  Location: Chr13:68608050-68849395 bp  Genetic Position: Chr13, Syntenic
Alliance: Tg(Tek-cre)12Flv page
Transgene
origin
Strain of Origin:  (C3H x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
 
Tg(Tek-cre)12Flv expression driven by 1 gene
 
Mutation detailsCre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. The transgene integrated into chromosome 13 causing a 241.3 Kb deletion and disrupting the following genes: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase), Fastkd3 (FAST kinase domains 3), 1700001L19Rik, Adcy2 (adenylate cyclase 2). The deletion results in a functional knock-out of Mtrr, Adcy2 and Fastkd3 in homozygous mice. Founder line 12 has a copy number of greater than 10. (J:68147, J:138838)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek (mouse)
Summary of all recombinase alleles driven by Tek.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
All:  380 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory