Gdnf^tm1Rosl
Targeted Allele Detail

Summary

• Symbol: Gdnf^tm1Rosl
• Name: glial cell line derived neurotrophic factor; targeted mutation 1, Arnon Rosenthal
• MGI ID: MGI:2136843
• Synonyms: Gdnf-, Gdnf^lacZ, GDNF-LZ
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^tm1Rosl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33808
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene followed by a neomycin cassette was inserted in frame after the codon corresponding to amino acid 102. This allele expresses a fusion protein consisting of the first 102 amino acids of GDNF fused to beta-galactosidase. (J:33808)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 18 strains or lines available

References

• Original: J:33808 Moore MW, et al., Renal and neuronal abnormalities in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):76-9
• All: 30 reference(s)