Analysis Tools
mortality/aging
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• 80% die by 16 months of age
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growth/size/body
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• noted as mice age
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digestive/alimentary system
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• grossly distended by large polyps
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• all mice >6 months of age have macroscopic gastrointestinal polyps; majority are found in glandular stomach with equal distribution in fundus, antrum, and pylorus
• in most animals, 1-3 large polyps (20-30 mm in diameter) originate in pylorus and protrude into duodenum
• all polyps have extensive well-developed smooth muscle component originating from central stalk contiguous with muscularis mucosa
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• results from protrusion of large polyps into lumen
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neoplasm
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• seen in one animal; incidence similar to age-matched controls
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• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls
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• seen in one animal; incidence similar to age-matched controls
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• seen in one animal; incidence similar to age-matched controls
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liver/biliary system
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• seen in one animal; incidence similar to age-matched controls
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• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls
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reproductive system
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• seen in one animal; incidence similar to age-matched controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Peutz-Jeghers syndrome | DOID:3852 |
OMIM:175200 |
J:79074 | |
