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Targeted Allele Detail
Symbol: Il10tm1Cgn
Name: interleukin 10; targeted mutation 1, University of Cologne
MGI ID: MGI:1857199
Synonyms: Il10-, IL-10-, IL-10KO, IL-10KO, IL-10 KO, Il10tmCgn
Gene: Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM
Alliance: Il10tm1Cgn page
Characterization of Il10tm1Cgn/Il10tm1Cgn mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:15222
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. (J:15222)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 27 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Il10tm1Cgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 15 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:  42 strains or lines available
Original:  J:15222 Kuhn R, et al., Interleukin-10-deficient mice develop chronic enterocolitis [see comments]. Cell. 1993 Oct 22;75(2):263-74
All:  1005 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory