Excel File Text File All mouse models of leukemia with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      acute myeloid leukemia Cebpatm8.1Nerl/Cebpatm8.1Nerl involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 J:136134 View
acute myeloid leukemia Crebbptm1Dli/Crebbp+ involves: 129S6/SvEvTac * C57BL/6 J:60630 View
acute myeloid leukemia Flt3tm1.1Dosm/Flt3+ B6.129(C)-Flt3tm1.1Dosm J:205200 View
acute myeloid leukemia Flt3tm1Dgg/Flt3+
Kmt2atm1Clgr/Kmt2a+		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J J:189096 View
acute myeloid leukemia Flt3tm1Dgg/Flt3tm1Dgg
Kmt2atm1Clgr/Kmt2a+		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J J:189096 View
acute myeloid leukemia Flt3tm2.1Dosm/Flt3+ B6.129(C)-Flt3tm2.1Dosm J:205200 View
acute myeloid leukemia Kmt2atm1Saam/Kmt2a+
Tg(Mx1-cre)1Cgn/0		 involves: 129S1/Sv * C57BL/6 * CBA J:140628 View
acute myeloid leukemia Kmt2atm2(MLLT3)Thr/Kmt2a+ involves: 129P2/OlaHsd J:56340 View
acute myeloid leukemia Tg(Vav1-Asxl1*Y588X)#Fcy/0 C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy J:257690 View
      acute lymphoblastic leukemia Ezh2tm2Sho/Ezh2tm2.1Sho
Tg(Mx1-cre)1Cgn/0		 involves: 129S1/Sv * C57BL/6 * CBA J:182211 View
acute lymphoblastic leukemia Ezh2tm2Sho/Ezh2tm2Sho
Tg(Mx1-cre)1Cgn/0		 involves: 129S1/Sv * C57BL/6 * CBA J:182211 View
acute lymphoblastic leukemia Kmt2atm1Saam/Kmt2a+
Tg(Mx1-cre)1Cgn/0		 involves: 129S1/Sv * C57BL/6 * CBA J:140628 View
acute lymphoblastic leukemia Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0		 involves: 129S4/SvJae * C57BL/6 * CBA J:169097 View
acute lymphoblastic leukemia Tg(CD2-Lmo2)#Thr/0 involves: C57BL/6 * CBA J:102058 View
acute lymphoblastic leukemia Tg(Lck-Notch3)#Issc/0 involves: C57BL/6 * DBA/2 J:63300 View
acute myeloid leukemia Arid4atm1Alb/Arid4atm1Alb involves: 129S7/SvEvBrd J:141004 View
acute myeloid leukemia Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+		 involves: 129S7/SvEvBrd J:141004 View
acute myeloid leukemia Mybl2tm1.1Jof/Mybl2+
Tg(Zp3-cre)3Mrt/0		 involves: 129S2/SvPas * C57BL/6 * FVB/N J:196804 View
acute myeloid leukemia Spi1tm1.3Dgt/Spi1tm1.3Dgt involves: 129 * BALB/c * C57BL/6 J:90331 View
chronic myeloid leukemia Chordc1tm1Mbra/Chordc1+ involves: 129 * C57BL/6 J:222040 View
chronic myeloid leukemia Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(Mx1-cre)1Cgn/0		 involves: 129 * C57BL/6 * CBA * SJL J:172442 View
chronic myeloid leukemia Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(VAV1-cre)1Graf/0		 involves: 129 * C57BL/6 * SJL J:172442 View
chronic myeloid leukemia Sh2b3tm1Paw/Sh2b3tm1Paw involves: 129S1/Sv * 129X1/SvJ J:161643 View
chronic myeloid leukemia Sipa1tm1Nm/Sipa1+ involves: 129P2/OlaHsd * C57BL/6 J:97239 View
chronic myeloid leukemia Sipa1tm1Nm/Sipa1tm1Nm involves: 129P2/OlaHsd * C57BL/6 J:97239 View
chronic myelomonocytic leukemia Kdm6atm1Cdcn/Kdm6atm1Cdcn
Tg(CAG-cre/Esr1*)5Amc/0		 involves: C57BL/6J * CBA J:263565 View
chronic myelomonocytic leukemia Kdm6atm1Cdcn/Y
Tg(CAG-cre/Esr1*)5Amc/0		 involves: C57BL/6J * CBA J:263565 View
familial chronic myelocytic leukemia-like syndrome Irf8myls/Irf8myls
Slc11a1r/Slc11a1r		 BXH2/TyJ J:97931 View
familial chronic myelocytic leukemia-like syndrome Irf8myls/Irf8myls
Slc11a1r/Slc11a1r		 involves: A/J * BXH2/TyJ J:97931 View
familial chronic myelocytic leukemia-like syndrome Irf8tm1Hor/Irf8+ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) J:36038 View
familial chronic myelocytic leukemia-like syndrome Irf8tm1Hor/Irf8tm1Hor either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) J:36038 View
lymphoid leukemia Tg(Lck-Tal1)4709Led/0 FVB/N-Tg(Lck-Tal1)4709Led J:36076 View
T-cell acute lymphoblastic leukemia Nbnem7Jpt/Nbntm2Zqw
Tg(VAV1-cre)1Graf/0		 involves: 129P2/OlaHsd J:277750 View
T-cell acute lymphoblastic leukemia Tg(H2-K-Hmga1)#Lmsr/0 involves: C57BL/6 * SJL J:90252 View
T-cell adult acute lymphocytic leukemia Gt(ROSA)26Sortm18(Zeb2)Jhai/Gt(ROSA)26Sortm18(Zeb2)Jhai
Tg(Cd4-cre)1Cwi/0		 involves: C57BL/6 * CD-1 * DBA/2 J:263520 View
T-cell adult acute lymphocytic leukemia Gt(ROSA)26Sortm18(Zeb2)Jhai/Gt(ROSA)26Sortm18(Zeb2)Jhai
Tg(Tek-cre)1Ywa/0		 involves: C57BL/6 * CD-1 * SJL J:263520 View
T-cell adult acute lymphocytic leukemia Tg(Lck-Tax)53Hall/0 involves: C57BL/6 J:129531, J:214623 View
      acute lymphoblastic leukemia Ikzf1tm1Kast/Ikzf1+
Tg(BCR/ABL)623Hkp/0		 involves: 129S2/SvPas * C57BL/6 * CBA J:160846 View
acute promyelocytic leukemia Pmltm1.1Ews/Pmltm1.1Ews
Tg(PML-RARA)556Kog/0		 FVB.Cg-Pmltm1.1Ews Tg(PML-RARA)556Kog J:262172 View
acute promyelocytic leukemia Tg(CTSG-ZBTB16/RARA)#Ppp/0
Zbtb16tm1Ppp/Zbtb16tm1Ppp		 involves: 129S1/Sv J:65878 View
Transgenes and
Other Mutations		     acute leukemia Tg(Ly6a-SET/NUP214)2969Gcg/0 involves: FVB/NJ J:142938 View
acute lymphoblastic leukemia Tg(Igh-HMGA2)#Cro/0 FVB/N-Tg(Igh-HMGA2)#Cro J:233225 View
acute myeloid leukemia Tg(CMV-SALL4_iB)#Chai/? Not Specified J:115037 View
acute myeloid leukemia Tg(Vav1-ERG)#Jpim/0 involves: C57BL/6 J:203438 View
acute promyelocytic leukemia Tg(CTSG-NUMA1/RARA)#Skr/0 involves: C57BL/6 J:88103 View
acute promyelocytic leukemia Tg(PML-RARA)556Kog/? involves: FVB/N J:39327 View
chronic lymphocytic leukemia Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946 View
chronic lymphocytic leukemia Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879 View
chronic lymphocytic leukemia Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf
Cd19tm1(cre)Cgn/Cd19+		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946 View
chronic lymphocytic leukemia Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Cd19tm1(cre)Cgn/Cd19+		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879 View
chronic lymphocytic leukemia Mirc30em1Hhzg/Mirc30em1Hhzg
Tg(Vav1-cre)#Cgp/0		 involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj J:320883 View
chronic lymphocytic leukemia Mirc30tm1.2Rdf/Mirc30tm1.2Rdf involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946 View
chronic lymphocytic leukemia Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0 FVB/N-Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro J:162077 View
chronic lymphocytic leukemia Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
Tg(Igh-V186.2-TCL1A)3Cro/0		 involves: C3H * C57BL/6 * FVB/N J:162077 View
chronic lymphocytic leukemia Tg(Igh-ROR1)1Kip/0 C57BL/6-Tg(Igh-ROR1)1Kip J:206368 View
chronic lymphocytic leukemia Tg(Igh-ROR1)1Kip/0
Tg(Igh-V186.2-TCL1A)3Cro/0		 B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro J:206368 View
chronic lymphocytic leukemia Tg(Igh-TCL1A)1Ypek/0 FVB/N-Tg(Igh-TCL1A)1Ypek J:160184 View
chronic lymphocytic leukemia Tg(Igh-V186.2-TCL1A)3Cro/0 B6.Cg-Tg(Igh-V186.2-TCL1A)3Cro J:206368 View
chronic lymphocytic leukemia Tg(Igh-V186.2-TCL1A)3Cro/0 involves: C3H * C57BL/6 J:76574 View
chronic lymphocytic leukemia Tg(Lck-TNFSF13)3919Mhah/0 B6.Cg-Tg(Lck-TNFSF13)3919Mhah J:94628 View
chronic myeloid leukemia Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Tg(Tal1-tTA)19Dgt/0
Tg(tetO-BCR/ABL1)2Dgt/0
TgTn(pb-sb-GrOnc)#aGsva/0		 involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N J:227558 View
chronic myeloid leukemia Tg(Ly6a-BCR/ABL1)IS1AIsg/0 involves: C57BL/6J * CBA J:144382 View
chronic myeloid leukemia Tg(Ly6a-BCR/ABL1)IS1BIsg/0 involves: C57BL/6J * CBA J:144382 View
chronic myeloid leukemia Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg/0 involves: C57BL/6J * CBA J:144382 View
chronic myeloid leukemia Tg(tetO-BCR/ABL1)2Dgt/0
Tg(Tal1-tTA)19Dgt/0		 involves: C57BL/6 * DBA/2 * FVB/N J:96511 View
leukemia Tg(Vav1-STAT5B*N642H)726Biat/0 C57BL/6NCrl-Tg(Vav1-STAT5B*N642H)726Biat J:257519 View
Additional
Complex
Models		     acute leukemia Cd3etm1Mal/Cd3etm1Mal
Tg(Tcrb-TCF3/PBX1)23Gusa/0		 involves: C3H * C57BL/6 * C57BL/6J J:95693 View
acute lymphoblastic leukemia Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+
TgTn(sb-T2/Onc)76Dla/0		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N J:174866 View
acute lymphoblastic leukemia Tcf3tm1(PBX1)Mlc/Tcf3+
Cd19tm1(cre)Cgn/Cd19+		 involves: 129P2/OlaHsd * C57BL/6 J:226241 View
acute lymphoblastic leukemia Tcf3tm1(PBX1)Mlc/Tcf3+
Cd79atm1(cre)Reth/Cd79a+		 involves: BALB/c * C57BL/6 J:226241 View
acute lymphoblastic leukemia Tcf3tm1(PBX1)Mlc/Tcf3+
Tg(Mx1-cre)1Cgn/0		 involves: C57BL/6 * C57BL/6J * CBA/J J:226241 View
acute lymphoblastic leukemia Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0		 involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros J:40868 View
acute lymphoblastic leukemia Zfp36l1tm1.1Tnr/Zfp36l1tm1.1Tnr
Zfp36l2tm1.1Tnr/Zfp36l2tm1.1Tnr
Tg(CD2-icre)4Kio/0		 involves: C57BL/6 * C57BL/10 * CBA/Ca * SJL J:162388 View
acute myeloid leukemia Ctsgtm2.1(PML/RARA)Ley/Ctsg+ involves: 129X1/SvJ * C57BL/6 J:84230, J:86458 View
acute myeloid leukemia Nr4a1tm1Jmi/Nr4a1tm1Jmi
Nr4a3tm1Omc/Nr4a3tm1Omc		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 J:121903 View
acute promyelocytic leukemia Tg(CTSG-RARA/ZBTB16)#Ppp/0
Tg(CTSG-ZBTB16/RARA)#Ppp/0		 Not Specified J:65878 View
acute promyelocytic leukemia Tg(CTSG-RARA/ZBTB16)#Sjch/0
Tg(CTSG-ZBTB16/RARA)#Sjch/0		 Not Specified J:194312 View
chronic lymphocytic leukemia Ightm1.1(Tag)Rwhe/Igh+ involves: 129P2/OlaHsd * C57BL/6 J:150315 View
chronic lymphocytic leukemia Ightm2.1(Tag)Rwhe/Igh+ involves: 129P2/OlaHsd * C57BL/6 J:150315 View
chronic lymphocytic leukemia Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0		 involves: 129S1/Sv * C57BL/6 * DBA/2J J:166158 View
chronic lymphocytic leukemia Is(14)1Rdf/Is(14)1Rdf
Is(14)5Rdf/Is(14)5Rdf
Cd19tm1(cre)Cgn/Cd19+		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879 View
chronic lymphocytic leukemia Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0		 involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J J:94116 View
chronic myeloid leukemia Dok1tm1Ppp/Dok1+
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: 129S1/Sv J:95334 View
chronic myeloid leukemia Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp		 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp J:95334 View
chronic myeloid leukemia Dok1tm1Ppp/Dok1tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: 129S1/Sv J:95334 View
chronic myeloid leukemia Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam		 B6.129-Dok1tm1Yyam Dok2tm1Yyam J:95335 View
chronic myeloid leukemia Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: C57BL/6 J:95335 View
chronic myeloid leukemia Dok1tm1Yyam/Dok1tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: C57BL/6 J:95335 View
chronic myeloid leukemia Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: 129S1/Sv J:95334 View
chronic myeloid leukemia Dok2tm1Ppp/Dok2tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: 129S1/Sv J:95334 View
chronic myeloid leukemia Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0		 involves: C57BL/6 J:95335 View
leukemia Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+
Lyz2tm1(cre)Ifo/Lyz2+		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 J:205605 View
lymphoid leukemia Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+		 involves: 129S4/SvJae * C57BL/6 J:171191 View

       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      acute myeloid leukemia Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0		 involves: 129S4/SvJae * C57BL/6 * CBA J:87429 View
acute myeloid leukemia Npm1tm1Hft/Npm1+ involves: 129 J:194999 View