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Lyz2tm1(cre)Ifo
Targeted Allele Detail
Summary
Symbol: Lyz2tm1(cre)Ifo
Name: lysozyme 2; targeted mutation 1, Irmgard Forster
MGI ID: MGI:1934631
Synonyms: LC, LCre, Lys-cre, LysCre, lysM/cre, LysMcre, LysMCre, LysMCre, LysM Cre, LysM-Cre, Lystm1(cre)Ifo, Lyz2Cre, Lyz2-Cre, Lyz-cre, LyzCre, (LyzM)-Cre
Gene: Lyz2  Location: Chr10:117113446-117118177 bp, - strand  Genetic Position: Chr10, 65.34 cM
Alliance: Lyz2tm1(cre)Ifo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67924
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Lyz2tm1(cre)Ifo expression driven by 1 gene
 
Mutation detailsAn NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. (J:67924)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lyz2 (mouse)
Summary of all recombinase alleles driven by Lyz2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Lyz2tm1(cre)Ifo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 14 strains available      Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:  41 strains or lines available
References
Original:  J:67924 Clausen BE, et al., Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999 Aug;8(4):265-77
All:  2413 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory