Lyz2 MGI Mouse Gene Detail - MGI:96897

Symbol

Lyz2
Name

lysozyme 2
Synonyms

Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp

Feature Type

protein coding gene
IDs

MGI:96897
NCBI Gene: 17105
Alliance

genome feature page
Transcription Start Sites

21 TSS

Sequence Map

Chr10:117113446-117118177 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 65.34 cM
Mapping Data

5 experiments

SNPs within 2kb

324 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96897	protein coding gene	Chr10:117113236-117118226 (-)
129S1/SvImJ	ENSMUSG00200024170	protein coding gene	Chr10:113523648-113528638 (-)
A/J	ENSMUSG00195020115	protein coding gene	Chr10:113958387-113963377 (-)
AKR/J	ENSMUSG00220014682	protein coding gene	Chr10:113531974-113536964 (-)
BALB/cJ	ENSMUSG00180015349	protein coding gene	Chr10:113975273-113980263 (-)
C3H/HeJ	ENSMUSG00175022883	protein coding gene	Chr10:113920516-113925506 (-)
C57BL/6NJ	ENSMUSG00215013675	protein coding gene	Chr10:113616558-113621548 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015831	protein coding gene	Chr10:110047620-110052290 (-)
CAST/EiJ	ENSTCUG00005030828	protein coding gene	Chr10:112921783-112926771 (-)
CBA/J	ENSMUSG00210020759	protein coding gene	Chr10:113770116-113775106 (-)
DBA/2J	ENSMUSG00185008363	protein coding gene	Chr10:113893162-113898152 (-)
FVB/NJ	ENSMUSG00205019328	protein coding gene	Chr10:113219251-113224241 (-)
JF1/MsJ	ENSUMUG00000015232	protein coding gene	Chr10:115182961-115187949 (-)
LP/J	ENSMUSG00230024118	protein coding gene	Chr10:115843175-115848165 (-)
NOD/ShiLtJ	ENSMUSG00190017897	protein coding gene	Chr10:114019740-114024730 (-)
NZO/HlLtJ	ENSMUSG00225017560	protein coding gene	Chr10:120098254-120103244 (-)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010015932	protein coding gene	Chr10:115523664-115528236 (-)
WSB/EiJ	ENSIUOG00005012941	protein coding gene	Chr10:113613444-113618434 (-)

Human Ortholog

LYZ, lysozyme

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYZ, lysozyme
Synonyms

AMYLD5, LYZF1, LZM
Links

HGNC:6740

NCBI Gene ID: 4069

UniProt: P61626
Chr Location

12q15; chr12:69348381-69354234 (+) GRCh38

MGI Vertebrate Homology

Lyz2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYZ
Gene Tree

Lyz2

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Mutations/Alleles

1 with disease annotations

References

4 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
411 phenotypes from multigenic genotypes
2 images
3582 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

18
Targeted

6
Genomic Mutations

1 involving Lyz2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

639
Tissues

24
cDNA Data

17
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS48694.1

Ensembl

ENSMUSG00000069516 (Evidence)
NCBI Gene

17105

			Length	Strain/Species	Flank
genomic	17105	NCBI Gene Model \| MGI Sequence Detail	4732	C57BL/6J	± kb
transcript	NM_017372	RefSeq \| MGI Sequence Detail	1057	ZRU/MplStud
polypeptide	P08905	UniProt \| EBI \| MGI Sequence Detail	148	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010030 lysozyme C-2

(term hierarchy)
PDB

1IVM
EC

3.2.1.17
InterPro Domains

IPR001916 Glycoside hydrolase, family 22

IPR019799 Glycoside hydrolase family 22 domain

IPR000974 Glycoside hydrolase, family 22, lysozyme

IPR023346 Lysozyme-like domain superfamily

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All nucleic 21

cDNA 17

Primer pair 3

Other 1

Antibodies 3

Microarray probesets 4

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MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899

Summaries

All 3671

Developmental Gene Expression 43

Diseases 4

Gene Ontology 9

Phenotypes 3582
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:391815 Gao Z, et al., Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction. Aging Cell. 2026 Apr;25(4):e70490

TSS for Lyz2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99432	Chr10:117118337-117118346 (-)	-165 bp
Tssr99431	Chr10:117118290-117118298 (-)	-117 bp
Tssr99430	Chr10:117118234-117118272 (-)	-76 bp
Tssr99429	Chr10:117118227-117118232 (-)	-53 bp
Tssr99428	Chr10:117118167-117118185 (-)	1 bp
Tssr99427	Chr10:117118148-117118162 (-)	22 bp
Tssr99426	Chr10:117116907-117116910 (-)	1,268 bp
Tssr99425	Chr10:117116685-117116720 (-)	1,474 bp
Tssr99424	Chr10:117116640-117116671 (-)	1,521 bp
Tssr99423	Chr10:117116572-117116609 (-)	1,586 bp
Tssr99422	Chr10:117114810-117114823 (-)	3,360 bp
Tssr99421	Chr10:117114078-117114101 (-)	4,087 bp
Tssr99420	Chr10:117114004-117114025 (-)	4,162 bp
Tssr99419	Chr10:117113932-117113967 (-)	4,227 bp
Tssr99418	Chr10:117113917-117113929 (-)	4,254 bp
Tssr99417	Chr10:117113903-117113910 (-)	4,270 bp
Tssr99416	Chr10:117113791-117113835 (-)	4,364 bp
Tssr99415	Chr10:117113741-117113768 (-)	4,422 bp
Tssr99414	Chr10:117113658-117113708 (-)	4,494 bp
Tssr99413	Chr10:117113569-117113594 (-)	4,595 bp
Tssr99412	Chr10:117113508-117113541 (-)	4,652 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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