About   Help   FAQ
Due to maintenance, access to MGI may be intermittent starting at 7:30AM ET on Friday, September 29.
Targeted Allele Detail
Symbol: Dok1tm1Ppp
Name: docking protein 1; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:3527270
Synonyms: p62dok-
Gene: Dok1  Location: Chr6:83007915-83010448 bp, - strand  Genetic Position: Chr6, 35.94 cM
Alliance: Dok1tm1Ppp page
Germline Transmission:  Earliest citation of germline transmission: J:95640
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was used to replace exons 1 through 4 and part of exon 5. Western blot analysis of spleen and thymus did not detect protein gene product. (J:95640)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Dok1tm1Ppp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok1 Mutation:  9 strains or lines available
Original:  J:95640 Di Cristofano A, et al., p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med. 2001 Aug 6;194(3):275-84
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory