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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dok1tm1Ppp
targeted mutation 1, Pier Paolo Pandolfi
MGI:3527270
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dok1tm1Ppp/Dok1tm1Ppp 129S1/Sv-Dok1tm1Ppp MGI:3574540
cx2
 		Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp 		129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp MGI:3574543
cx3
 		Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp 		129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp MGI:4443009
cx4
 		Dok1tm1Ppp/Dok1tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp 		129S1/Sv-Dok1tm1Ppp Dok3tm1Ppp MGI:4443011
cx5
 		Dok1tm1Ppp/Dok1tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: 129S1/Sv MGI:3574541
cx6
 		Dok1tm1Ppp/Dok1+
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: 129S1/Sv MGI:3574545


Genotype
MGI:3574540
hm1
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Genetic
Background		 129S1/Sv-Dok1tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell proliferation ( J:95640 )
• thymocytes display increased proliferation in response to ConA stimulation

neoplasm
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 38% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

cellular
abnormal T cell proliferation ( J:95640 )
• thymocytes display increased proliferation in response to ConA stimulation
increased fibroblast proliferation ( J:95640 )
• primary embryonic fibroblasts display increased proliferation in response to PDGF stimulation

hematopoietic system
abnormal T cell proliferation ( J:95640 )
• thymocytes display increased proliferation in response to ConA stimulation
abnormal bone marrow cell morphology/development ( J:95640 )
• bone marrow derived mast cells display increased proliferation in response to low concentrations of cytokines; however, when deprived of cytokines mutant cells underwent apoptosis similar to wild-type cells

respiratory system
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 38% of mice develop lung adenocarcinoma compared with 7% of wild-type mice




Genotype
MGI:3574543
cx2
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Genetic
Background		 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:95334 )
• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system
increased bone marrow cell number ( J:95334 )
• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
increased leukocyte cell number ( J:95334 )
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
abnormal leukocyte physiology ( J:95334 )
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system
increased leukocyte cell number ( J:95334 )
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
abnormal leukocyte physiology ( J:95334 )
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

respiratory system
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

growth/size/body
enlarged spleen ( J:95334 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95334




Genotype
MGI:4443009
cx3
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp
Genetic
Background		 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Dok3tm1Ppp mutation (0 available); any Dok3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158011 )
• mice begin to die at around 1 year of age unlike wild-type mice

respiratory system
pulmonary hyperplasia ( J:158011 )
• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal
increased lung tumor incidence ( J:158011 )
• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
increased bronchioalveolar stem cell number ( J:158011 )
• the number and percentages of bronchioalveolar stem cells are increased compared to in wild-type mice
abnormal pulmonary alveolus morphology ( J:158011 )
• at 12 weeks, mice exhibit alveolar hyperplasia with scattered bronchioaveolar stem cells unlike in wild-type mice
increased type II pneumocyte number ( J:158011 )
• the number and percentages of alveolar type 2 cells are increased compared to in wild-type mice

neoplasm
increased chronic myelocytic leukemia incidence ( J:158011 )
• at 20 months, mice exhibit an expansion of Mac-1+ and GR-1+ Mac-1+ cells compared with wild-type mice
• however, Mac-1+ and GR-1+ Mac-1+ cell numbers are normal at 3 months
increased lung tumor incidence ( J:158011 )
• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

immune system

hematopoietic system

growth/size/body
pulmonary hyperplasia ( J:158011 )
• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal




Genotype
MGI:4443011
cx4
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp
Genetic
Background		 129S1/Sv-Dok1tm1Ppp Dok3tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
Dok3tm1Ppp mutation (0 available); any Dok3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 51% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

respiratory system
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 51% of mice develop lung adenocarcinoma compared with 7% of wild-type mice




Genotype
MGI:3574541
cx5
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:95334 )
• loss of Dok1 shortened lifespan to about 285 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm
increased leukemia incidence ( J:95334 )
• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95334




Genotype
MGI:3574545
cx6
Allelic
Composition		 Dok1tm1Ppp/Dok1+
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (18 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:95334 )
• loss of Dok1 shortened lifespan to about 307 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm
increased leukemia incidence ( J:95334 )
• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95334




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory