About   Help   FAQ
On Friday, September 29 at 7:30AM ET, access to MGI will be intermittent for a short time due to maintenance.
Targeted Allele Detail
Symbol: Dok2tm1Ppp
Name: docking protein 2; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:3527246
Gene: Dok2  Location: Chr14:71003476-71015935 bp, + strand  Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
Alliance: Dok2tm1Ppp page
Germline Transmission:  Earliest citation of germline transmission: J:95334
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExon 2 was disrupted by the insertion of a cassette containing EGFP and neo (in inverse orientation). Western blot analysis of splenocytes did not detect protein gene product. EGFP expression was not reported. (J:95334)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Dok2tm1Ppp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok2 Mutation:  11 strains or lines available
Original:  J:95334 Niki M, et al., Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med. 2004 Dec 20;200(12):1689-95
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory