Tg(CTSG-RARA/ZBTB16)#Ppp
Transgene Detail

Summary

• Symbol: Tg(CTSG-RARA/ZBTB16)#Ppp
• Name: transgene insertion, Pier Paolo Pandolfi
• MGI ID: MGI:3527936
• Synonyms: RARalpha-PLZF, RARA-PLZF, RARA/PLZF
• Transgene: Tg(CTSG-RARA/ZBTB16)#Ppp Location: unknown
• Alliance: Tg(CTSG-RARA/ZBTB16)#Ppp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-RARA/ZBTB16)#Ppp expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

  human

  ZBTB16 (7704)

  Zbtb16

  (MGI:103222)

• Mutation details: The human derived RARA/ZBTB16 fusion protein was placed unter the expressional control of the human cathepsin-G promoter (CTSG). 2-36 copies of the transgene were incorporated in the DNA in a head to tail and/or tail to head configuration. Transgene expression was detected in the bone marrow. Five lines were made. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:65878)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTSG-RARA/ZBTB16)#Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65878 He LZ, et al., Two critical hits for promyelocytic leukemia. Mol Cell. 2000 Nov;6(5):1131-41
• All: 3 reference(s)