Phenotypes for Irf8 Slc11a1 MGI:3578958 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: A/J * BXH2/TyJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^myls mutation (1 available); any Irf8 mutation (31 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24