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Targeted Allele Detail
Symbol: Sh2b3tm1Paw
Name: SH2B adaptor protein 3; targeted mutation 1, Tony Pawson
MGI ID: MGI:2383957
Synonyms: Lnk-
Gene: Sh2b3  Location: Chr5:121953551-121975709 bp, - strand  Genetic Position: Chr5, 61.99 cM
Alliance: Sh2b3tm1Paw page
Primary splenomegaly and extramedullary hematopoiesis in Sh2b3tm1Paw/Sh2b3tm1Paw mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77248
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details1.6 Kb of sequence, encompassing exons 2 through 7, was replaced with a neomycin selection cassette. The absence of transcript and protein was determined in homozygous mutant mice by Northern and Western blot analyses. (J:77248)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sh2b3 Mutation:  17 strains or lines available
Original:  J:77248 Velazquez L, et al., Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002 Jun 17;195(12):1599-611
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory