Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Biomodels Austria
• MGI ID: MGI:8259352
• Synonyms: Gt(ROSA)26Sor^{tm1(STAT5B-N642H)}Biat, STAT5B^N642H
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350923
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STAT5B (6777)

  Stat5b

  (MGI:103035)

  Contains p.N642H mutation

• Mutation details: A CAG promoter, loxP-flanked neo-STOP cassette, human STAT5B with a p.N642H mutation and C-terminal V5 tag, FRT-flanked internal ribosome entry site (IRES)-controlled enhanced green fluorescent protein (EGFP), and pA were inserted into the locus. p.N642H is a gain-of-function mutation described in various forms of lymphoproliferative disorders that causes enhanced and prolonged tyrosine phosphorylation. (J:350923)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:350923 Klein K, et al., A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia. Blood. 2024 Jun 13;143(24):2474-2489
• All: 1 reference(s)