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Stat5b Gene Detail
Summary
  • Symbol
    Stat5b
  • Name
    signal transducer and activator of transcription 5B
  • Feature Type
    protein coding gene
  • IDs
    MGI:103035
    NCBI Gene: 20851
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100671557-100741407 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103035
protein coding gene Chr11:100671557-100741550 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019171
protein coding gene Chr11:103554033-103629023 (-)
A/J MGP_AJ_G0019139
protein coding gene Chr11:99233313-99302018 (-)
AKR/J MGP_AKRJ_G0019108
protein coding gene Chr11:102318613-102391737 (-)
BALB/cJ MGP_BALBcJ_G0019113
protein coding gene Chr11:99719529-99788794 (-)
C3H/HeJ MGP_C3HHeJ_G0018922
protein coding gene Chr11:102477938-102551693 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019562
protein coding gene Chr11:106762175-106836431 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017188
protein coding gene Chr11:96651917-96723733 (-)
CAST/EiJ MGP_CASTEiJ_G0018476
protein coding gene Chr11:103465450-103538567 (-)
CBA/J MGP_CBAJ_G0018891
protein coding gene Chr11:111226357-111300913 (-)
DBA/2J MGP_DBA2J_G0019003
protein coding gene Chr11:98769104-98840300 (-)
FVB/NJ MGP_FVBNJ_G0018993
protein coding gene Chr11:98308461-98380475 (-)
LP/J MGP_LPJ_G0019072
protein coding gene Chr11:104113339-104182940 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019024
protein coding gene Chr11:110802423-110874596 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019600
protein coding gene Chr11:102629687-102704718 (-)
PWK/PhJ MGP_PWKPhJ_G0018239
protein coding gene Chr11:99811129-99884940 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018031
protein coding gene Chr11:102375878-102446338 (-)
WSB/EiJ MGP_WSBEiJ_G0018525
protein coding gene Chr11:102623214-102698572 (-)



Homology
more
  • Human Ortholog
    STAT5B, signal transducer and activator of transcription 5B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT5B, signal transducer and activator of transcription 5B
  • Synonyms
    GHISID2, STAT5
  • Links
    NCBI Gene ID: 6777
    neXtProt AC: NX_P51692
    UniProt: P51692

  • Chr Location
    17q21.2; chr17:42199176-42288633 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with human STAT5B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 4 alleles in 15 genetic backgrounds
    80 phenotypes from multigenic genotypes
    207 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this are reduced in size and mammary glands secrete reduced levels of some milk proteins during lactation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20851 NCBI Gene Model | MGI Sequence Detail 69851 C57BL/6J ±  kb
    transcript NM_001362682 RefSeq | MGI Sequence Detail 7252 ZRU/MplStud  
    polypeptide P42232 UniProt | EBI | MGI Sequence Detail 786 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000002092 signal transducer and activator of transcription 5b
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR046994 STAT5a/5b, coiled-coil domain
      IPR035858 STAT5a/5b, DNA-binding domain
      IPR035886 STAT5b, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 6
      cDNA 91
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-23873
    References
    more
    • Summaries
      All 338
      Developmental Gene Expression 22
      Gene Ontology 24
      Phenotypes 207
    • Earliest
      J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
    • Latest
      J:340839 Grockowiak E, et al., Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms. Nat Cancer. 2023 Aug;4(8):1193-1209

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    02/20/2024
    MGI 6.23
    The Jackson Laboratory