Symbol
Name
ID

Stat5b
signal transducer and activator of transcription 5B
MGI:103035

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Decreased serum insulin-like growth factor 1
Disease(s) Associated with STAT5B	Increased circulating IgE level	Decreased serum insulin-like growth factor 1
growth hormone insensitivity syndrome with immune dysregulation 2

Mouse Phenotypes

decreased insulin secretion

impaired adaptive thermogenesis

increased circulating glucose level

increased circulating insulin level

decreased circulating insulin-like growth factor I level

increased circulating leptin level

increased circulating growth hormone level

increased circulating free fatty acids level

increased circulating triglyceride level

increased circulating iron level

increased circulating interleukin-17 level

decreased oxygen consumption

impaired glucose tolerance

insulin resistance

increased liver iron level

decreased urine major urinary protein level

Availability

Mouse Genotype

Stat5b^tm1Hwd/Stat5b^tm1Hwd

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Ins2-cre)25Mgn/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Pdx1-cre)89.1Dam/0 (conditional)

Myf5^tm3(cre)Sor/Myf5⁺
Stat5b^tm1Mam/Stat5b^tm1Mam (conditional)

Myf5^tm3(cre)Sor/Myf5⁺
Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Alb1-cre)1Dlr/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Nes-cre)1Kln/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Cd4-cre)1Cwi/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Tek-cre)1Ywa/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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