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Targeted Allele Detail
Symbol: Dok2tm1Yyam
Name: docking protein 2; targeted mutation 1, Yuji Yamanashi
MGI ID: MGI:3527416
Gene: Dok2  Location: Chr14:71003476-71015935 bp, + strand  Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
Alliance: Dok2tm1Yyam page
Germline Transmission:  Earliest citation of germline transmission: J:95335
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo-bpA cassette was used to disrupt the entire coding region, including the initiation and termination codons. Immunoblot analysis of bone marrow cells did not detect protein gene product. (J:95335)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok2 Mutation:  11 strains or lines available
Original:  J:95335 Yasuda T, et al., Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med. 2004 Dec 20;200(12):1681-7
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory