Cebpa^tm8.1Nerl
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm8.1Nerl
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 8.1, Claus Nerlov
• MGI ID: MGI:3796230
• Synonyms: Cbpa^L, Cebpa^Lp30
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm8.1Nerl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136134
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and results in a missense mutation that produces a STOP codon upstream of the coding region of p42. The absence of p42 and presence of p30 protein products was confirmed by western blot analysis of liver extracts. (J:136134)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 16 strains or lines available

References

• Original: J:136134 Kirstetter P, et al., Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell. 2008 Apr;13(4):299-310
• All: 5 reference(s)