Phenotypes Associated with This Genotype

Genotype
MGI:4850007

• Allelic Composition: Tg(Igh-TCL1A)1Ypek/0
• Genetic Background: FVB/N-Tg(Igh-TCL1A)1Ypek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:160184 )

• in all mice at 16 to 20 months of age

abnormal lymphocyte physiology ( J:160184 )

• splenic CD19+CD5+CD23+ and total CD19+CD5+ cells exhibit proliferation unlike wild-type cells

decreased IgG1 level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG2a level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG2b level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG3 level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgM level ( J:160184 )

• 4- to 8-fold at 18 months

abnormal circulating chemokine level ( J:160184 )

• MCP-1 serum levels are increased 2-fold compared to in wild-type mice

increased circulating tumor necrosis factor level ( J:160184 )

• 8-fold

abnormal humoral immune response ( J:160184 )

• SRBC-injected mice exhibit an 8-fold reduction in serum anti-SRBC antibodies unlike similarly treated wild-type mice

neoplasm

increased chronic lymphocytic leukemia incidence ( J:160184 )

• in elderly mice

homeostasis/metabolism

abnormal circulating chemokine level ( J:160184 )

• MCP-1 serum levels are increased 2-fold compared to in wild-type mice

increased circulating tumor necrosis factor level ( J:160184 )

• 8-fold

hematopoietic system

enlarged spleen ( J:160184 )

• in all mice at 16 to 20 months of age

abnormal lymphocyte physiology ( J:160184 )

• splenic CD19+CD5+CD23+ and total CD19+CD5+ cells exhibit proliferation unlike wild-type cells

decreased IgG1 level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG2a level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG2b level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgG3 level ( J:160184 )

• 4- to 8-fold at 18 months

decreased IgM level ( J:160184 )

• 4- to 8-fold at 18 months

growth/size/body

enlarged spleen ( J:160184 )

• in all mice at 16 to 20 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:160184