About   Help   FAQ
Due to maintenance, access to MGI may be intermittent starting at 7:30AM ET on Friday, September 29.
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm4(CAG-hsb5)Nki
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, The Netherlands Cancer Institute
MGI ID: MGI:4410291
Synonyms: Rosa26flox-SB, Rosa26Lox66SBLox71
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm4(CAG-hsb5)Nki page
Germline Transmission:  Earliest citation of germline transmission: J:172071
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Transposase)
Mutation:    Insertion
Mutation detailsAn inverted cassette containing a hyperactive sleeping beauty transposase variant hsb5 under the control of the CAG promoter flanked lox66 and lox71 sites was cloned into the Gt(Rosa)26Sor locus. (J:172071, J:178629)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm4(CAG-hsb5)Nki
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  830 strains or lines available
Original:  J:172071 Vassiliou GS, et al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011 May;43(5):470-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory