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Transgene Detail
Symbol: Tg(tetO-BCR/ABL1)2Dgt
Name: transgene insertion 2, Daniel G Tenen
MGI ID: MGI:2387680
Synonyms: BCR-ABL, BCR-ABL1, BCR-ABL stg, p210-BCR-ABL, p210 BCR-ABL1 transponder, Tg(BCR/ABL1)2Dgt, Tg(BCR/ABL1)3Dgt, TRE-BCR-ABL, TRE-BCR/ABL, TRE-P10 BCR/ABL, TRE-p210-BCR-ABL
Transgene: Tg(tetO-BCR/ABL1)2Dgt  Location: unknown  
Alliance: Tg(tetO-BCR/ABL1)2Dgt page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
Tg(tetO-BCR/ABL1)2Dgt expresses 2 genes
Mutation detailsThe transgene contains a cDNA encoding the human p210 BCR-ABL1 fusion protein (B3A2 form; J:86227) under transcriptional control of the tetracycline-responsive element (tetO; also called TRE) fused to a minimal cytomegalovirus (CMV) promoter. In doubly transgenic mice expressing a tetracycline transactivator or reverse transactivator protein under the control of a ubiquitous or tissue-specific promoter, expression of the BCL-ABL1 fusion gene can be controlled temporally by withdrawal or administration of a tetracycline analog. (J:72377)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
This record is also representative of lines 3 and 4 that were also generated; all of these lines exhibit a similar phenotype in combination with Tg(MMTVtTA)1Mam. Bitransgenic mice with this transgene in combination with Tg(MMTVtTA)1Mam, when tetracycline administration is stopped, are models for B cell acute lymphoblastic leukemia (ALL); line 2 exhibits the greatest leukemia susceptibility (Figure 1). (J:72377)
Original:  J:72377 Huettner CS, et al., Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet. 2000 Jan;24(1):57-60
All:  45 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory