Phenotypes Associated with This Genotype

Genotype
MGI:4455033

• Allelic Composition: Kmt2a^{tm2(MLLT3)Thr}/Kmt2a⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:56340 )

• predominantly acute myeloid leukemia (AML) involving immature myeloblasts and extramedullary leukemia

• a minority of the observed leukemia is acute lymphoblastic leukemia (ALL)

• 50% of heterozygotes succumb to AML at 5 months of age

• almost all mice develop malignancy within 1 1/2 years

hematopoietic system

enlarged spleen ( J:56340 )

abnormal definitive hematopoiesis ( J:56340 )

• abnormal hematopoietic differentiation resulting in an accumulation of Mac-1/Gr-1 double-positive mature myeloid cells in the bone marrow preceded the onset of AML, as early as 6 days of age

immune system

enlarged spleen ( J:56340 )

liver/biliary system

enlarged liver ( J:56340 )

renal/urinary system

pale kidney ( J:56340 )

growth/size/body

enlarged liver ( J:56340 )

enlarged spleen ( J:56340 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:56340