Phenotypes Associated with This Genotype

Genotype
MGI:5517439

• Allelic Composition: Tg(CTSG-RARA/ZBTB16)#Sjch/0; Tg(CTSG-ZBTB16/RARA)#Sjch/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired hematopoiesis ( J:194312 )

• impairment of normal hematopoiesis

neoplasm

increased acute promyelocytic leukemia incidence ( J:194312 )

• mutants develop myeloid leukemia resembling human t(11;17) acute promyelocytic leukemia, showing an accumulation of immature myeloblastic cells in hematopoietic tissues and infiltration of nonhematopoietic organs, including the liver, lung, gastrointestinal tract, and kidney

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute promyelocytic leukemia		DOID:0060318	OMIM:612376	J:194312