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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pten
phosphatase and tensin homolog
MGI:109583
558 phenotypes from 21 alleles in 80 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal endometrium morphology J:170203
abnormal maternal decidual layer morphology J:170203
abnormal myometrium morphology J:170203
abnormal placenta labyrinth morphology J:170203
abnormal placenta vasculature J:170203
abnormal trophoblast layer morphology J:170203
decreased litter size J:170203
decreased uterine NK cell number J:170203
endometrium fibrosis J:170203
endometrium hyperplasia J:170203
reduced female fertility J:170203
normal reproductive system phenotype J:187754
uterus hyperplasia J:170203
Cd19tm1(cre)Cgn/Cd19+
Ptentm1Hwu/Ptentm1Hwu
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal B cell negative selection J:155314
abnormal B cell physiology J:83213
abnormal class switch recombination J:114881
abnormal plasma cell morphology J:114881
decreased IgG level J:114881
decreased spleen germinal center number J:83213
increased B cell apoptosis J:83213
increased B cell number J:83213
increased B cell proliferation J:83213, J:155314
increased B-1 B cell number J:83213
increased IgM level J:114881
increased marginal zone B cell number J:83213
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Ptentm1Hwu/Ptentm1Hwu
involves: 129P2/OlaHsd * 129S4/SvJae 		normal immune system phenotype J:83213
Cnptm1(cre)Kan/Cnp+
Ptentm1Hwu/Ptentm1Hwu
B6N.129-Cnptm1(cre)Kan Ptentm1Hwu 		tomacula J:236408
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
involves: 129 * 129S4/SvJae * BALB/c * C57BL/6 		decreased tumor-free survival time J:130367
endometrium hyperplasia J:130367
increased gastrointestinal tumor incidence J:130367
increased incidence of tumors by chemical induction J:130367
increased prostate gland tumor incidence J:130367
increased prostate intraepithelial neoplasia incidence J:130367
increased skin squamous cell carcinoma incidence J:130367
increased T cell derived lymphoma incidence J:130367
increased tumor incidence J:130367
intestine polyps J:130367
prostate gland hyperplasia J:130367
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * C57BL/6 		enlarged lymph nodes J:170965
enlarged spleen J:170965
hunched posture J:170965
increased acute lymphoblastic leukemia incidence J:170965
increased spleen weight J:170965
premature death J:170965
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Y
Ptentm2Mak/Ptentm2Mak
involves: 129P2/OlaHsd * C57BL/6 		increased prostate gland adenocarcinoma incidence J:144357
increased prostate intraepithelial neoplasia incidence J:144357
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		increased prostate gland adenocarcinoma incidence J:153425
increased prostate intraepithelial neoplasia incidence J:153425, J:191327
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal uterus physiology J:162027
decreased uterus weight J:218222
endometrium hyperplasia J:162027
increased endometrial carcinoma incidence J:162027, J:218222
increased papilloma incidence J:218222
increased uterus weight J:162027, J:218222
premature death J:218222
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		endometrium hyperplasia J:139053
increased endometrial carcinoma incidence J:139053
premature death J:139053
Ptenm1un/Ptenm1un
involves: C3HeB/FeJ * C57BL/6J 		cardia bifida J:98216
embryonic growth arrest J:98216
embryonic lethality during organogenesis, complete penetrance J:98216
incomplete embryo turning J:98216
Ptentm1.1Gle/Pten+
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		endometrium hyperplasia J:158751
increased adrenal gland tumor incidence J:158751
increased lymphoma incidence J:158751
increased mammary gland tumor incidence J:158751
increased prostate gland tumor incidence J:158751
increased stomach tumor incidence J:158751
increased T cell derived lymphoma incidence J:158751
increased thyroid tumor incidence J:158751
Ptentm1.1Gle/Ptentm1.1Gle
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		abnormal embryonic tissue morphology J:158751
abnormal gastrulation J:158751
abnormal rostral-caudal axis patterning J:158751
embryonic lethality, complete penetrance J:158751
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * BALB/c 		abnormal brain vasculature morphology J:110567
abnormal metastatic potential J:110567
abnormal olfactory bulb morphology J:110567
abnormal tumor incidence J:110567
abnormal uterus morphology J:110567
increased hemangioma incidence J:110567
increased mammary adenocarcinoma incidence J:110567
increased prostate gland tumor incidence J:110567
lymphoid hyperplasia J:110567
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal tumor incidence J:110567
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * C57BL/6NTac 		increased lymphoma incidence J:170965
increased thyroid adenoma incidence J:170965
Ptentm1.1Hwu/Ptentm1.1Hwu
involves: 129S4/SvJae * BALB/c 		abnormal pericardium development J:110567
embryonic lethality during organogenesis, complete penetrance J:110567
open neural tube J:110567
wavy neural tube J:110567
Ptentm1.1Jaes/Ptentm1.1Jaes
B6.129S6(FVB)-Ptentm1.1Jaes 		abnormal CNS synaptic transmission J:234430
abnormal synaptic depression J:234430
Ptentm1.1Mro/Pten+
Not Specified 		increased metastatic potential J:236514
increased pheochromocytoma incidence J:236514
Ptentm1.1Mro/Ptentm1.1Mro
involves: BALB/cJ 		abnormal embryo development J:77123
embryonic lethality J:77123
increased tumor incidence J:77123
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
involves: FVB/N 		increased mammary gland tumor incidence J:153747
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0
involves: 129 * FVB/NCr 		abnormal thyroid follicular cell morphology J:225245
Ptentm1.1Yxy/Ptentm1.1Yxy
involves: C57BL/6 		abnormal cellular respiration J:308567
abnormal endocytosis J:290673
abnormal glutamate-mediated receptor currents J:256248
abnormal mitochondrial morphology J:308567
abnormal mitophagy J:308567
abnormal olfactory bulb development J:290673
abnormal olfactory bulb mitral cell layer morphology J:290673
normal behavior/neurological phenotype J:256248
normal cardiovascular system phenotype J:308567
normal cellular phenotype J:290673, J:308567
disorganized mitochondrial cristae J:308567
fast extinction of fear memory J:256248
normal growth/size/body region phenotype J:256248
impaired olfaction J:290673
impaired spatial learning J:256248
increased glutamic acid level J:290673
increased myocardial fiber mitochondrial DNA content J:308567
increased myocardial infarct size J:308567
increased susceptibility to induced morbidity/mortality J:308567
increased susceptibility to myocardial ischemic injury J:308567
normal nervous system phenotype J:256248, J:290673
reduced long-term potentiation J:256248
normal reproductive system phenotype J:256248
Ptentm1.2Mwst/Pten+
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		endometrium hyperplasia J:158751
increased adrenal gland tumor incidence J:158751
increased gastrointestinal tumor incidence J:158751
increased lymphoma incidence J:158751
increased mammary adenoacanthoma incidence J:158751
increased mammary gland tumor incidence J:158751
increased prostate gland tumor incidence J:158751
increased stomach tumor incidence J:158751
increased T cell derived lymphoma incidence J:158751
increased thyroid tumor incidence J:158751
increased uterus carcinoma incidence J:158751
Ptentm1.2Mwst/Ptentm1.2Mwst
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		abnormal embryonic tissue morphology J:158751
abnormal gastrulation J:158751
abnormal rostral-caudal axis patterning J:158751
embryonic lethality, complete penetrance J:158751
Ptentm1Engc/Pten+
either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1) 		increased brain weight J:200739
megacephaly J:200739
Ptentm1Engc/Pten+
involves: CD-1 		abnormal cell physiology J:197051
Ptentm1Engc/Ptentm1Engc
either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1) 		increased brain weight J:197051
megacephaly J:197051
Ptentm1Engc/Ptentm1Engc
involves: CD-1 		abnormal cerebral cortex pyramidal cell morphology J:210487
abnormal cerebral hemisphere morphology J:210487
abnormal hippocampus granule cell morphology J:210487
abnormal hippocampus pyramidal cell morphology J:210487
abnormal microglial cell physiology J:210487
abnormal social investigation J:210487
astrocytosis J:210487
decreased body size J:210487
enlarged cerebellum J:210487
impaired balance J:210487
increased astrocyte number J:210487
increased brain size J:210487
increased cell proliferation J:210487
increased oligodendrocyte number J:210487
Ptentm1Hwu/Pten+
involves: 129S4/SvJae * BALB/c 		abnormal tumor incidence J:110567
Ptentm1Hwu/Pten+
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 		increased prostate intraepithelial neoplasia incidence J:93902
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0
B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand 		abnormal thyroid gland morphology J:197590
decreased thyroxine level J:197590
increased thyroid tumor incidence J:197590
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal thyroid follicle morphology J:197590
enlarged thyroid gland J:197590
increased thyroxine level J:197590
thyroid gland hyperplasia J:197590
Ptentm1Hwu/Pten+
Tg(KRT14-cre)#Smr/0
involves: 129S4/SvJae * C57BL/6J * SJL/J 		increased mammary adenocarcinoma incidence J:138927
increased mammary gland tumor incidence J:138927
premature death J:138927
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae 		abnormal muscle fiber morphology J:169364
abnormal response to injury J:165283
increased prostate gland adenocarcinoma incidence J:144810
increased prostate intraepithelial neoplasia incidence J:144810
Ptentm1Hwu/Ptentm1Hwu
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJae * FVB/N 		abnormal response to cardiac infarction J:149180
decreased myocardial infarct size J:149180
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal pregnancy J:142150
decreased litter size J:142150
increased granulosa cell tumor incidence J:142150, J:222579
increased metastatic potential J:142150
normal reproductive system phenotype J:142150
Ptentm1Hwu/Ptentm1Hwu
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal brain white matter morphology J:161841
abnormal corpus callosum morphology J:161841
abnormal myelin sheath morphology J:161841
abnormal oligodendrocyte morphology J:161841
abnormal salivary gland morphology J:161841
abnormal Schwann cell morphology J:161841
abnormal sciatic nerve morphology J:161841
cataract J:161841
hypermyelination J:161841
increased brain size J:161841
megacolon J:161841
premature death J:161841
reduced fertility J:161841
Ptentm1Hwu/Ptentm1Hwu
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal alveolar macrophage morphology J:148947
abnormal cytokine level J:148947
abnormal macrophage chemotaxis J:148947
abnormal neutrophil physiology J:114699, J:145331, J:148947
decreased susceptibility to bacterial infection J:148947
decreased susceptibility to bacterial infection induced morbidity/mortality J:148947
impaired neutrophil recruitment J:148947
increased susceptibility to bacterial infection J:148947
increased susceptibility to bacterial infection induced morbidity/mortality J:148947
lung inflammation J:148947
pulmonary edema J:148947
Ptentm1Hwu/Ptentm1Hwu
Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		no abnormal phenotype detected J:131721
Ptentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129S4/SvJae * C57BL/6 		abnormal behavioral response to xenobiotic J:153622
abnormal dopaminergic neuron morphology J:153622
abnormal midbrain morphology J:153622
abnormal nervous system physiology J:153622
abnormal striatum morphology J:153622
abnormal substantia nigra pars compacta morphology J:153622
abnormal substantia nigra pars reticulata morphology J:153622
normal behavior/neurological phenotype J:153622
increased dopamine level J:153622
neuron hypertrophy J:153622
Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA 		abnormal fatty acids level J:88441
abnormal liver morphology J:218587
decreased circulating free fatty acids level J:88441
decreased circulating glucose level J:88441
decreased circulating insulin level J:88441
decreased circulating leptin level J:88441
decreased total body fat amount J:88441
enlarged liver J:88441, J:171445
hepatic steatosis J:88441, J:160759, J:218587
impaired lipolysis J:88441
improved glucose tolerance J:88441
increased cholangiocarcinoma incidence J:218587
increased circulating alanine transaminase level J:218587
increased hepatocellular carcinoma incidence J:218587
increased hepatocyte apoptosis J:218587
increased hepatocyte proliferation J:218587
increased insulin sensitivity J:88441
increased liver glycogen level J:88441
increased liver triglyceride level J:88441, J:160759
increased liver tumor incidence J:218587
increased liver weight J:88441, J:160759
macrovesicular hepatic steatosis J:171445
oxidative stress J:218587
pale liver J:88441
Ptentm1Hwu/Ptentm1Hwu
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJae * C57BL/6J * FVB/NJ 		normal neoplasm J:237232
Ptentm1Hwu/Ptentm1Hwu
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJae * FVB/N 		bile duct hyperplasia J:111718
increased cholangiocarcinoma incidence J:111718
increased hepatocellular carcinoma incidence J:111718
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		normal endocrine/exocrine gland phenotype J:102226
Ptentm1Hwu/Ptentm1Hwu
Tg(Camk2a-cre)T50Stl/0
Tg(Thy1-EGFP)MJrs/0
involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA 		abnormal dendrite morphology J:145970
increased brain size J:145970
Ptentm1Hwu/Ptentm1Hwu
Tg(CD2-icre)4Kio/0
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca 		enlarged thymus J:216983
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N 		abnormal definitive hematopoiesis J:135172
enlarged liver J:135172
enlarged lymph nodes J:135172
enlarged spleen J:135172
enlarged thymus J:135172
increased acute lymphoblastic leukemia incidence J:135172
increased acute promyelocytic leukemia incidence J:135172
increased leukocyte cell number J:135172
increased neutrophil cell number J:135172
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR 		abnormal ureter morphology J:137073
abnormal urinary bladder urothelium morphology J:137073
normal renal/urinary system phenotype J:137073
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * ICR 		abnormal endometrium morphology J:137442
abnormal epididymis epithelium morphology J:137442
abnormal reproductive system morphology J:137442
abnormal seminal vesicle morphology J:137442
abnormal vas deferens morphology J:137442
endometrium hyperplasia J:137442
normal neoplasm J:137442
Ptentm1Hwu/Ptentm1Hwu
Tg(Ckmm-cre)5Khn/?
involves: 129S4/SvJae * FVB 		decreased circulating glucose level J:169364
decreased circulating insulin level J:169364
enhanced skeletal muscle regeneration J:169364
Ptentm1Hwu/Ptentm1Hwu
Tg(Cr2-cre)3Cgn/0
involves: 129S4/SvJae 		preweaning lethality, complete penetrance J:157297
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae 		abnormal luteolysis J:138315
abnormal ovarian follicle morphology J:138315
decreased granulosa cell apoptosis J:138315
enhanced female fertility J:138315
enlarged ovary J:138315
impaired luteal cell differentiation J:138315
increased corpora lutea number J:138315
increased granulosa cell proliferation J:138315
increased superovulation rate J:138315
normal neoplasm J:138315
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre)1Dcas/0
involves: 129S4/SvJae * FVB/N 		abnormal ovary physiology J:138697
enlarged ovary J:138697
reduced female fertility J:138697
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0
involves: 129S4/SvJae * FVB/N 		abnormal primordial ovarian follicle morphology J:138697
enlarged ovary J:138697
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp1-cre)1Jig/0
involves: 129S4/SvJae * FVB/N 		abnormal renal/urinary system morphology J:106662
abnormal urinary bladder urothelium morphology J:106662
abnormal urination J:106662
hydronephrosis J:106662
increased carcinoma incidence J:106662
increased colon adenocarcinoma incidence J:106662
increased metastatic potential J:106662
increased prostate gland tumor incidence J:106662
increased renal carcinoma incidence J:106662
increased squamous cell carcinoma incidence J:106662
increased urethra carcinoma incidence J:106662
increased urinary bladder carcinoma incidence J:106662
premature death J:106662
prostate gland anterior lobe hyperplasia J:106662
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp4-cre)1Abel/0
involves: 129S4/SvJae 		abnormal cytokine level J:97588
normal adipose tissue phenotype J:97588
decreased circulating insulin level J:97588
improved glucose tolerance J:97588
increased insulin sensitivity J:97588
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0
B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo 		abnormal corpus luteum morphology J:131827
abnormal estrous cycle J:131827
abnormal oocyte morphology J:131827
abnormal ovarian follicle morphology J:131827
abnormal ovarian folliculogenesis J:131827
abnormal primordial ovarian follicle morphology J:131827
absent primordial ovarian follicles J:131827
decreased primordial ovarian follicle number J:131827
enlarged ovary J:131827
female infertility J:131827
increased follicle stimulating hormone level J:131827
increased luteinizing hormone level J:131827
premature ovarian failure J:131827
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0
involves: 129S4/SvJae * C57BL/6 		abnormal primordial ovarian follicle morphology J:151696
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/?
involves: 129S4/SvJae * C57BL/6J 		abnormal primordial ovarian follicle morphology J:155357
Ptentm1Hwu/Ptentm1Hwu
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJae * FVB/N 		abnormal Bergmann glial cell differentiation J:100428
abnormal Bergmann glial cell morphology J:100428
abnormal cerebellar foliation J:100428
abnormal cerebellar granule cell morphology J:100428
abnormal cerebellar granule layer morphology J:100428
abnormal cerebellar Purkinje cell layer J:100428
abnormal cerebellum development J:100428
ectopic Bergmann glia cells J:100428
ectopic Purkinje cell J:100428
enlarged cerebellum J:100428
increased brain size J:100428
lethality at weaning, complete penetrance J:100428
megacephaly J:100428
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd 		abnormal neuron differentiation J:146630
abnormal neuronal precursor proliferation J:146630
abnormal olfaction J:146630
abnormal olfactory bulb morphology J:146630
abnormal postnatal subventricular zone morphology J:146630
abnormal response to CNS ischemic injury J:146630
abnormal response to novel odor J:146630
increased neuronal precursor cell number J:146630
normal neoplasm J:146630, J:154673
Ptentm1Hwu/Ptentm1Hwu
Tg(GZMB-cre)1Jcb/0
involves: 129S4/SvJae * FVB/N 		abnormal CD8-positive, alpha-beta T cell physiology J:164425
decreased interleukin-2 secretion J:164425
Ptentm1Hwu/Ptentm1Hwu
Tg(Ins2-cre)25Mgn/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA 		abnormal pancreatic beta cell morphology J:170129
increased pancreatic beta cell mass J:170129
postnatal growth retardation J:170129
Ptentm1Hwu/Ptentm1Hwu
Tg(Ins2-cre)25Mgn/0
involves: 129S4/SvJae * C57BL/6 * DBA 		abnormal pancreas physiology J:106937
abnormal pancreatic beta cell morphology J:170206
decreased cellular sensitivity to oxidative stress J:106937
decreased susceptibility to injury J:106937
enlarged pancreatic islets J:106937
normal homeostasis/metabolism phenotype J:170206
hypoglycemia J:106937
improved glucose tolerance J:170206
increased body weight J:170206
increased insulin secretion J:170206
increased insulin sensitivity J:170206
increased pancreatic beta cell mass J:170206
increased pancreatic beta cell number J:106937
increased pancreatic beta cell proliferation J:106937
increased pancreatic islet number J:106937
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr 		abnormal epidermal layer morphology J:199362
hyperkeratosis J:199362
increased skin hamartoma incidence J:199362
increased skin papilloma incidence J:199362
skin lesions J:199362
thick epidermis J:199362
thick epidermis suprabasal layer J:199362
thick skin J:199362
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
involves: 129S4/SvJae * C57BL/6J * SJL/J 		abnormal hair shaft morphology J:138927
abnormal nipple morphology J:138927
abnormal vibrissa follicle morphology J:138927
acanthosis J:138927
decreased survivor rate J:138927
enlarged hair follicles J:138927
enlarged thyroid gland J:138927
flaky skin J:138927
hyperkeratosis J:138927
increased mammary adenocarcinoma incidence J:138927
increased mammary gland tumor incidence J:138927
increased skin papilloma incidence J:138927
increased skin tumor incidence J:138927
increased thyroid tumor incidence J:138927
postnatal lethality, incomplete penetrance J:138927
premature death J:138927
skin lesions J:138927
wrinkled skin J:138927
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJae * FVB 		abnormal branching of the mammary ductal tree J:78415
mammary gland duct hyperplasia J:78415
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
involves: 129S4/SvJae * FVB/N 		normal neoplasm J:133305
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)#Tfln/0
involves: 129S4/SvJae 		abnormal branching of the mammary ductal tree J:78415
abnormal involution of the mammary gland J:78415
abnormal mammary gland epithelium morphology J:78415
abnormal mammary gland growth during pregnancy J:78415
abnormal mammary gland lobule morphology J:78415
increased fibroadenoma incidence J:78415
increased mammary adenocarcinoma incidence J:78415
increased mammary gland tumor incidence J:78415
mammary gland duct hyperplasia J:78415
mammary gland hyperplasia J:78415
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu 		abnormal liver size J:232645
anemia J:232645
decreased B cell number J:232645
decreased lymphocyte cell number J:232645
decreased T cell number J:232645
enlarged spleen J:232645
increased granulocyte number J:232645
increased liver weight J:232645
increased macrophage cell number J:232645
increased monocyte cell number J:232645
increased spleen weight J:232645
increased T cell acute lymphoblastic leukemia incidence J:232645
increased tumor incidence J:232645
premature death J:232645
thrombocytosis J:232645
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu 		abnormal blood cell morphology/development J:109085
abnormal hematopoietic stem cell physiology J:109085
decreased bone marrow cell number J:109085
enlarged thymus J:109085
extramedullary hematopoiesis J:109085
increased acute lymphoblastic leukemia incidence J:109085
increased acute promyelocytic leukemia incidence J:109085
increased leukemia incidence J:109085
premature death J:109085
spleen hyperplasia J:109085
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA 		abnormal platelet activation J:165893
decreased bleeding time J:165893
increased platelet aggregation J:165893
thrombocytosis J:165893
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		enlarged spleen J:169097
enlarged thymus J:169097
increased acute lymphoblastic leukemia incidence J:169097
intestine polyps J:118329
premature death J:169097
Ptentm1Hwu/Ptentm1Hwu
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * FVB/N 		abnormal brain morphology J:73255
abnormal brainstem morphology J:73255
abnormal cerebellum morphology J:73255
abnormal cortical ventricular zone morphology J:73255
abnormal hippocampus layer morphology J:73255
absent cerebellar foliation J:73255
eyelids open at birth J:73255
increased brain size J:73255
increased brain weight J:73255
increased neuronal precursor cell number J:73255
megacephaly J:73255
neonatal lethality, complete penetrance J:73255
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0
B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand 		abnormal thyroid follicle morphology J:197590
abnormal thyroid gland morphology J:197590
decreased thyroxine level J:197590
enlarged thyroid gland J:197590
increased thyroid adenoma incidence J:197590
increased thyroid-stimulating hormone level J:197590
postnatal lethality, complete penetrance J:197590
thyroid gland hyperplasia J:197590
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal lung development J:167962
abnormal lung morphology J:167962
abnormal thyroid gland morphology J:197590
decreased susceptibility to injury J:167962
enlarged thyroid gland J:197590
normal homeostasis/metabolism phenotype J:197590
increased club cell number J:167962
increased lung endothelial cell proliferation J:167962
normal mortality/aging J:197590
pulmonary hyperplasia J:167962
thyroid gland hyperplasia J:197590
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0
involves: 129S4/SvJae * C57BL/6 		increased club cell number J:157922
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2 		female infertility J:142106
increased prostate gland adenocarcinoma incidence J:142106
increased prostate gland tumor incidence J:142106
increased prostate intraepithelial neoplasia incidence J:138565
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 		abnormal prostate gland epithelium morphology J:93902
abnormal prostate gland morphology J:124208
abnormal prostate gland physiology J:93902, J:124208
abnormal renal/urinary system physiology J:124208
decreased tumor incidence J:124208
decreased tumor-free survival time J:124208
enlarged prostate gland J:93902
increased prostate gland adenocarcinoma incidence J:93902, J:124208
increased prostate gland tumor incidence J:124208
increased prostate gland weight J:124208
increased prostate intraepithelial neoplasia incidence J:93902, J:106650
premature death J:93902
prostate gland epithelial hyperplasia J:93902
prostate gland hyperplasia J:93902
prostate gland inflammation J:93902
pyelonephritis J:124208
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		enlarged prostate gland anterior lobe J:170965
increased carcinoma incidence J:268934
increased metastatic potential J:268934
increased prostate gland adenocarcinoma incidence J:184935, J:212219, J:268934
increased prostate gland tumor incidence J:170965, J:172730, J:268934
increased prostate gland weight J:170965
increased prostate intraepithelial neoplasia incidence J:131932, J:212219, J:268934
normal mortality/aging J:212219
prostate gland hyperplasia J:170965
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)20Fwan/?
involves: 129S4/SvJae * C57BL/6 * FVB/NCrl 		increased prostate gland adenocarcinoma incidence J:238768
increased prostate intraepithelial neoplasia incidence J:238768
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal centroacinar cell of Langerhans morphology J:102226
abnormal exocrine pancreas morphology J:102226
abnormal pancreatic acinar cell morphology J:102226
abnormal pancreatic acinus morphology J:102226
enlarged pancreatic islets J:102226
normal homeostasis/metabolism phenotype J:102226
increased malignant tumor incidence J:102226
increased pancreatic acinar cell number J:102226
increased pancreatic ductal adenocarcinoma incidence J:102226
increased pancreatic intraepithelial neoplasia incidence J:102226
pancreatic islet hyperplasia J:102226
premature death J:102226
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre/Esr1*)35.10Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA 		pancreatic islet hyperplasia J:102226
Ptentm1Hwu/Ptentm1Hwu
Tg(Pgc-cre,-secNluc)#Hcz/0
involves: 129S4/SvJae 		increased mammary adenocarcinoma incidence J:338079
Ptentm1Hwu/Ptentm1Hwu
Tg(Plp1-cre/ERT2)1Ueli/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal brain white matter morphology J:161841
abnormal corpus callosum morphology J:161841
abnormal myelin sheath morphology J:161841
abnormal optic nerve morphology J:161841
hypermyelination J:161841
Ptentm1Hwu/Ptentm1Hwu
Tg(Scgb1a1-cre)1Tauc/0
involves: 129S4/SvJae * C57BL/6 		normal respiratory system phenotype J:136369
Ptentm1Hwu/Ptentm1Hwu
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N 		abnormal lung epithelium morphology J:146355
abnormal respiratory epithelium morphology J:146355
bronchial epithelial hyperplasia J:146355
bronchiolar epithelial hyperplasia J:146355
increased club cell number J:146355
increased solitary pulmonary neuroendocrine cell number J:146355
normal neoplasm J:146355
Ptentm1Hwu/Ptentm1Hwu
Tg(TPO-cre)1Shk/0
involves: 129S4/SvJae * FVB/NCr 		enlarged thyroid gland J:177181
Ptentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0
B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru 		abnormal digestion J:155110
abnormal enteric ganglia morphology J:155110
abnormal enteric nervous system morphology J:155110
abnormal enteric neuron morphology J:155110
abnormal intestine morphology J:155110
distended cecum J:155110
hyperpigmentation J:155110
postnatal lethality, complete penetrance J:155110
slow postnatal weight gain J:155110
Ptentm1Hwu/Ptentm1Hwu
Tg(Vil1-cre)997Gum/0
involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL 		abnormal duodenum morphology J:150553
abnormal intestinal enteroendocrine cell morphology J:150553
abnormal intestinal goblet cell morphology J:150553
abnormal intestinal mucosa morphology J:150553
abnormal intestine morphology J:150553
abnormal jejunum morphology J:150553
abnormal Paneth cell morphology J:150553
abnormal small intestinal crypt cell proliferation J:150553
abnormal small intestinal villus morphology J:150553
abnormal small intestine crypts of Lieberkuhn morphology J:150553
abnormal small intestine morphology J:150553
branched small intestinal villi J:150553
Ptentm1Hwu/Ptentm1Hwu
Tg(Zp3-cre)93Knw/0
B6.Cg-Ptentm1Hwu Tg(Zp3-cre)93Knw 		normal reproductive system phenotype J:151696
Ptentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+
B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu 		abnormal lung development J:192736
abnormal lung morphology J:192736
abnormal lung vasculature morphology J:192736
abnormal lung-associated mesenchyme development J:192736
abnormal vascular development J:192736
cyanosis J:192736
decreased blood oxygen capacity J:192736
hemorrhage J:192736
lethality throughout fetal growth and development, incomplete penetrance J:192736
neonatal lethality, complete penetrance J:192736
respiratory distress J:192736
Ptentm1Mak/Pten+
B6.129P2-Ptentm1Mak 		abnormal embryonic tissue morphology J:93530
abnormal placenta morphology J:93530
decreased embryo size J:93530
embryonic lethality during organogenesis, incomplete penetrance J:93530
enlarged allantois J:93530
failure of chorioallantoic fusion J:93530
failure of initiation of embryo turning J:93530
increased adrenal gland tumor incidence J:93530
increased endometrial carcinoma incidence J:93530
increased lymphoma incidence J:93530
increased tumor incidence J:93530
kinked neural tube J:93530
open neural tube J:93530
Ptentm1Mak/Pten+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal seminiferous tubule morphology J:50437
colon polyps J:50437
endometrium hyperplasia J:63478
enlarged Peyer's patches J:63478
increased adrenal gland tumor incidence J:63478
increased carcinoma incidence J:50437
increased endometrial carcinoma incidence J:63478
increased fibroadenoma incidence J:63478
increased hamartoma incidence J:63478
increased incidence of tumors by ionizing radiation induction J:50437
increased leukemia incidence J:50437
increased lymphoma incidence J:63478
increased mammary adenocarcinoma incidence J:63478
increased mammary gland tumor incidence J:63478
increased prostate gland tumor incidence J:63478
increased T cell derived lymphoma incidence J:50437
increased tumor incidence J:50437
Ptentm1Mak/Ptentm1Mak
involves: 129P2/OlaHsd * C57BL/6J 		abnormal allantois morphology J:50437
abnormal brain development J:50437
abnormal developmental patterning J:50437
abnormal somite development J:50437
disorganized embryonic tissue J:50437
embryonic growth retardation J:50437
embryonic lethality during organogenesis, complete penetrance J:50437
failure of chorioallantoic fusion J:50437
Ptentm1Mro/Pten+
Tg(Pbsn-cre)4Prb/0
involves: C57BL/6 * DBA/2 		increased prostate intraepithelial neoplasia incidence J:184533
Ptentm1Mro/Pten+
Tg(KLK3-cre)D4Trp/0
involves: 129P2/OlaHsd * FVB 		abnormal prostate gland epithelium morphology J:99524
increased prostate gland adenocarcinoma incidence J:99524
increased prostate gland tumor incidence J:99524
increased prostate gland weight J:99524
increased prostate intraepithelial neoplasia incidence J:99524
prostate gland hyperplasia J:99524
Ptentm1Mro/Ptentm1Mro
Tg(En2-cre)22Alj/0
Not Specified 		abnormal cerebellar molecular layer J:77123
abnormal cerebellum development J:77123
abnormal cerebellum external granule cell layer morphology J:77123
abnormal cerebellum morphology J:77123
abnormal cerebellum vermis morphology J:77123
abnormal neuronal migration J:77123
absent cerebellar foliation J:77123
ataxia J:77123
decreased locomotor activity J:77123
ectopic Purkinje cell J:77123
enlarged cerebellum J:77123
impaired balance J:77123
normal neoplasm J:77123
Purkinje cell degeneration J:77123
Ptentm1Mro/Ptentm1Mro
Tg(KLK3-cre)D4Trp/0
involves: 129P2/OlaHsd * FVB 		prostate gland epithelial hyperplasia J:99524
Ptentm1Mro/Ptentm1Mro
Tg(Pcp2-cre)756Mro/0
involves: FVB/N 		abnormal cerebellar Purkinje cell layer J:77123
abnormal Purkinje cell dendrite morphology J:77123
abnormal Purkinje cell morphology J:77123
Purkinje cell degeneration J:77123
Ptentm1Ppp/Pten+
involves: 129S1/Sv * C57BL/6J 		increased malignant tumor incidence J:49532
Ptentm1Ppp/Ptentm1Ppp
involves: 129S1/Sv * C57BL/6J 		embryonic lethality between implantation and somite formation, complete penetrance J:49532
Ptentm1Ppp/Ptentm2Ppp
involves: 129S1/Sv * C57BL/6 		abnormal prostate gland morphology J:86212
increased prostate gland tumor incidence J:86212
prenatal lethality, incomplete penetrance J:86212
prostate gland anterior lobe hyperplasia J:86212
prostate gland dorsolateral lobe hyperplasia J:86212
prostate gland epithelial hyperplasia J:86212
Ptentm1Rdp/Ptentm1Rdp
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal pigmentation phenotype J:151023
Ptentm1Rps/Pten+
B6.129S1-Ptentm1Rps 		abnormal social investigation J:144937
decreased prepulse inhibition J:144937
increased brain weight J:144937
megacephaly J:144937
Ptentm1Rps/Pten+
B6.129S1-Ptentm1Rps/Nci 		abnormal behavior J:235927
abnormal social investigation J:235927
decreased aggression towards male mice J:235927
increased stereotypic behavior J:235927
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J 		abnormal prostate gland epithelium morphology J:75085
increased prostate intraepithelial neoplasia incidence J:75085
Ptentm1Rps/Pten+
involves: 129S1/Sv * C57BL/6J 		abnormal lymph node B cell domain morphology J:53065
abnormal thyroid gland morphology J:53065
endometrium hyperplasia J:53065
enlarged spleen J:53065
enlarged thymus J:53065
increased leukemia incidence J:53065
increased liver adenoma incidence J:53065
increased lymphoma incidence J:53065
increased prostate intraepithelial neoplasia incidence J:53065
increased teratoma incidence J:53065
increased thyroid carcinoma incidence J:53065
increased tumor incidence J:53065
intestine polyps J:53065
lymph node hyperplasia J:53065
premature death J:53065
Ptentm1Rps/Ptentm1Rps
involves: 129S1/Sv * C57BL/6J 		disorganized embryonic tissue J:53065
embryonic lethality between implantation and somite formation, complete penetrance J:53065
Ptentm2.1Gle/Pten+
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		abnormal thyroid follicular cell morphology J:158751
endometrium hyperplasia J:158751
increased adrenal gland tumor incidence J:158751
increased lymphoma incidence J:158751
increased mammary adenoacanthoma incidence J:158751
increased mammary gland tumor incidence J:158751
increased prostate gland tumor incidence J:158751
increased T cell derived lymphoma incidence J:158751
increased thyroid tumor incidence J:158751
Ptentm2.1Gle/Ptentm2.1Gle
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		abnormal embryonic tissue morphology J:158751
abnormal gastrulation J:158751
abnormal rostral-caudal axis patterning J:158751
embryonic lethality, complete penetrance J:158751
Ptentm2.1Ppp/Ptentm2.1Ppp
involves: 129S1/Sv 		abnormal dendrite morphology J:181347
abnormal excitatory postsynaptic currents J:181347
abnormal miniature excitatory postsynaptic currents J:181347
abnormal synaptic transmission J:181347
increased dendritic spine density J:181347
increased miniature excitatory postsynaptic current amplitude J:181347
increased miniature excitatory postsynaptic current frequency J:181347
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Dhh-cre)1Mejr/0
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL 		abnormal nervous system morphology J:195067
abnormal sciatic nerve morphology J:195067
abnormal trigeminal nerve morphology J:195067
increased neurofibrosarcoma incidence J:195067
premature death J:195067
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0
involves: 129S1/Sv * 129X1/SvJ 		increased prostate intraepithelial neoplasia incidence J:192348
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * C57BL/6 * DBA/2 		abnormal prostate gland epithelium morphology J:86212
abnormal prostate gland morphology J:86212
enlarged prostate gland J:86212
increased prostate gland adenocarcinoma incidence J:100683, J:163589
increased prostate gland tumor incidence J:86212, J:100683
increased prostate intraepithelial neoplasia incidence J:100683, J:163589, J:200002, J:239660
prostate gland epithelial hyperplasia J:86212, J:100683
prostate gland hyperplasia J:86212
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0
involves: 129S1/Sv * C57BL/6 		abnormal prostate gland morphology J:86212
enlarged prostate gland J:86212
increased prostate gland tumor incidence J:86212
prostate gland epithelial hyperplasia J:86212
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk 		decreased thyroid-stimulating hormone level J:165293
increased thyroid adenoma incidence J:165293
increased thyroid carcinoma incidence J:165293
increased thyroxine level J:165293
premature death J:165293
thyroid gland hyperplasia J:165293
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129S1/Sv * FVB 		normal pigmentation phenotype J:151023
Ptentm2.1Ppp/Ptentm2.1Ppp
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S1/Sv * 129X1/SvJ 		increased germinal center B cell number J:164283
increased IgG1 level J:164283
increased T follicular helper cell number J:164283
Ptentm2Hwu/Pten+
involves: 129S4/SvJae * BALB/c 		abnormal tumor incidence J:110567
Ptentm2Hwu/Pten+
involves: 129S4/SvJae * C57BL/6 		abnormal tumor incidence J:110567
Ptentm2Mak/Ptentm2Mak
involves: 129P2/OlaHsd 		abnormal astrocyte physiology J:176586
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA 		abnormal cellular cholesterol metabolism J:90905
abnormal hepatocyte morphology J:90905
abnormal liver sinusoid morphology J:90905
decreased circulating insulin level J:90905
decreased fasting circulating glucose level J:90905
enlarged liver J:90905
increased circulating alanine transaminase level J:90905
increased circulating alkaline phosphatase level J:90905
increased circulating aspartate transaminase level J:90905
increased hepatocellular carcinoma incidence J:90905
increased hepatocyte number J:90905
increased hepatocyte proliferation J:90905
increased insulin sensitivity J:90905
increased liver adenoma incidence J:90905
increased liver triglyceride level J:90905
increased liver weight J:90905
increased metastatic potential J:90905
increased saturated fatty acids level J:90905
Mallory bodies J:90905
microvesicular hepatic steatosis J:90905
oxidative stress J:90905
pale liver J:90905
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal hepatocyte morphology J:138099
abnormal hepatocyte physiology J:220381
abnormal liver morphology J:138099
enlarged liver J:138099
hepatic steatosis J:138099
increased circulating alanine transaminase level J:138099
increased circulating alkaline phosphatase level J:138099
increased hepatocellular carcinoma incidence J:138099
increased hepatocyte proliferation J:138099
increased liver adenoma incidence J:138099
increased liver cholesterol level J:138099
increased liver triglyceride level J:138099
liver fibrosis J:138099
liver inflammation J:138099
Mallory bodies J:138099
pale liver J:138099
Ptentm2Mak/Ptentm2Mak
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB 		abnormal heart left ventricle morphology J:79151
abnormal heart morphology J:79151
cardiac hypertrophy J:79151
decreased cardiac muscle contractility J:79151
enlarged heart J:79151
increased myocardial fiber size J:79151
Ptentm2Mak/Ptentm2Mak
Tg(Col2a1-cre)1Xya/?
involves: 129P2/OlaHsd 		abnormal bone marrow cavity morphology J:143447
abnormal bone structure J:143447
abnormal cartilage morphology J:143447
abnormal chondrocyte morphology J:143447
abnormal epiphyseal plate morphology J:143447
abnormal long bone epiphysis morphology J:143447
abnormal long bone hypertrophic chondrocyte zone J:143447
abnormal long bone morphology J:143447
abnormal tumor susceptibility J:143447
ectopic cartilage J:143447
hindlimb paralysis J:143447
increased body length J:143447
increased bone mineral density J:143447
kyphosis J:143447
long tail J:143447
premature death J:143447
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal behavior J:143082
normal digestive/alimentary phenotype J:143082
endometrium hyperplasia J:143082
hepatic steatosis J:143082
increased hepatocellular carcinoma incidence J:143082
increased liver weight J:143082
increased lymphoma incidence J:143082
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre/ERT)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA 		normal renal/urinary system phenotype J:169565
Ptentm2Mak/Ptentm2Mak
Tg(Eno2-cre)39Jme/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal behavior J:109635
abnormal dendrite morphology J:109635
abnormal dentate gyrus morphology J:109635
abnormal hippocampal mossy fiber morphology J:109635
abnormal hippocampus CA1 region morphology J:109635
abnormal innervation J:109635
abnormal maternal nurturing J:109635
abnormal nest building behavior J:109635
abnormal sexual interaction J:109635
abnormal social investigation J:109635
abnormal synapse morphology J:109635
abnormal synaptic vesicle number J:109635
ectopic neuron J:109635
impaired spatial learning J:109635
increased anxiety-related response J:109635
increased brain weight J:109635
increased dendritic spine density J:109635
increased dentate gyrus size J:109635
increased locomotor activity J:109635
increased startle reflex J:109635
increased stereotypic behavior J:109635
increased thigmotaxis J:109635
megacephaly J:109635
neuron hypertrophy J:109635
reduced sensorimotor gating J:109635
sporadic seizures J:109635
thickened cerebral cortex J:109635
Ptentm2Mak/Ptentm2Mak
Tg(Fabp1-cre)1Jig/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal urinary bladder urothelium morphology J:113388
abnormal urothelium morphology J:113388
hydronephrosis J:113388
increased incidence of tumors by chemical induction J:113388
increased urinary bladder transitional cell carcinoma incidence J:113388
Ptentm2Mak/Ptentm2Mak
Tg(Gfap-cre)1Sbk/0
involves: 129P2/OlaHsd 		abnormal cerebellar foliation J:75500
abnormal cerebellar granule cell morphology J:75500
abnormal cerebellar molecular layer J:75500
abnormal cerebellum external granule cell layer morphology J:75500
abnormal cerebellum morphology J:75500
abnormal dentate gyrus morphology J:75500
abnormal hippocampus morphology J:75500
abnormal hippocampus pyramidal cell layer J:75500
abnormal Purkinje cell morphology J:75500
abnormal spike wave discharge J:149829
ataxia J:75500, J:149829
decreased hippocampus pyramidal cell number J:75500
decreased Purkinje cell number J:75500
gliosis J:75500
hippocampal neuron degeneration J:75500
hydrocephaly J:75500
increased brain size J:75500, J:149829
increased hamartoma incidence J:75500
lethargy J:75500
megacephaly J:75500, J:149829
neuron hypertrophy J:149829
premature death J:75500, J:149829
seizures J:75500
tonic-clonic seizures J:149829
Ptentm2Mak/Ptentm2Mak
Tg(Hoxb7-cre)5526Cmb/0
involves: 129P2/OlaHsd 		abnormal glomerular capillary morphology J:122953
abnormal kidney collecting duct morphology J:122953
abnormal renal glomerulus morphology J:122953
decreased body size J:122953
ectopic ureteric bud J:122953
impaired branching involved in ureteric bud morphogenesis J:122953
postnatal lethality, complete penetrance J:122953
Ptentm2Mak/Ptentm2Mak
Tg(KLK3-cre)13Saa/0
involves: 129P2/OlaHsd * C57BL/6 		increased metastatic potential J:214242
increased prostate gland adenocarcinoma incidence J:214242
increased prostate gland tumor incidence J:214242
increased prostate intraepithelial neoplasia incidence J:214242
premature death J:214242
Ptentm2Mak/Ptentm2Mak
Tg(KRT5-cre)1Xya/0
involves: 129P2/OlaHsd 		epidermal hyperplasia J:101602
hair follicle outer root sheath hyperplasia J:101602
Ptentm2Mak/Ptentm2Mak
Tg(MMTV-cre)#Tfln/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:224955
increased mammary gland tumor incidence J:224955
increased mammary gland tumor incidence in breeding females J:224955
increased myoepithelioma incidence J:224955
increased spindle cell carcinoma incidence J:224955
Ptentm2Mak/Ptentm2Mak
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
involves: 129P2/OlaHsd 		abnormal cerebellar granule cell morphology J:237990
abnormal cerebellar molecular layer J:237990
abnormal cerebellar Purkinje cell layer J:237990
abnormal cerebellum morphology J:237990
abnormal nervous system physiology J:237990
ataxia J:237990
ectopic cerebellar granule cells J:237990
hydrocephaly J:237990
increased brain size J:237990
lethargy J:237990
megacephaly J:237990
normal neoplasm J:237990
premature death J:237990
seizures J:237990
thin cerebellar granule layer J:237990
Ptentm2Mak/Ptentm2Mak
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J 		abnormal alveolocapillary membrane morphology J:127405
abnormal lung development J:127405
abnormal lung saccule morphology J:127405
abnormal pulmonary alveolus epithelial cell morphology J:127405
abnormal type I pneumocyte morphology J:127405
abnormal type II pneumocyte morphology J:127405
bronchiolar epithelial hyperplasia J:127405
cyanosis J:127405
decreased alveolar lamellar body number J:127405
decreased surfactant secretion J:127405
decreased survivor rate J:127405
hypoxia J:127405
increased bronchioalveolar stem cell number J:127405
increased incidence of tumors by chemical induction J:127405
increased lung adenocarcinoma incidence J:127405
increased lung squamous cell carcinoma incidence J:127405
increased mesenchymal cell proliferation involved in lung development J:127405
neonatal lethality, incomplete penetrance J:127405
pulmonary hyperplasia J:127405
respiratory acidosis J:127405
respiratory distress J:127405
respiratory failure J:127405
small lung saccule J:127405
Ptentm2Mak/Ptentm2Mak
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal digestive/alimentary phenotype J:143082
ruffled hair J:143082
Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		increased mammary adenocarcinoma incidence J:224955
increased mammary gland tumor incidence J:224955
increased mammary gland tumor incidence in breeding females J:224955
increased myoepithelioma incidence J:224955
increased spindle cell carcinoma incidence J:224955
Tg(Pten)1Srn/0
involves: C57BL/6 * CBA 		abnormal adipose tissue morphology J:182671
abnormal brown adipose tissue morphology J:182671
abnormal brown adipose tissue physiology J:182671
abnormal cell physiology J:182671
abnormal excitatory postsynaptic potential J:234430
decreased body fat mass J:182671
decreased body weight J:182671
decreased brown fat cell lipid droplet size J:182671
decreased cell proliferation J:182671
decreased circulating cholesterol level J:182671
decreased circulating insulin level J:182671
decreased circulating insulin-like growth factor I level J:182671
decreased circulating leptin level J:182671
decreased embryo size J:182671
decreased epididymal fat pad weight J:182671
decreased fasting circulating glucose level J:182671
decreased incidence of tumors by chemical induction J:182671
decreased susceptibility to diet-induced hepatic steatosis J:182671
decreased white fat cell size J:182671
enhanced coordination J:182671
extended life span J:182671
increased adipocyte glucose uptake J:182671
increased basal metabolism J:182671
increased energy expenditure J:182671
increased insulin sensitivity J:182671
polyphagia J:182671
postnatal lethality, incomplete penetrance J:182671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory