Bcl6btm2Dent/Bcl6btm2Dent
Rag1tm1Mom/Rag1tm1Mom
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6
|
abnormal blood cell morphology/development |
J:123621
|
|
decreased lymphocyte cell number |
J:123621
|
C1galt1ptl1/C1galt1ptl1
Rag1tm1Bal/Rag1tm1Bal
involves: 129S4/SvJae * C57BL/6
|
abnormal kidney morphology |
J:115272
|
|
abnormal renal tubule morphology |
J:115272
|
|
decreased renal glomerulus number |
J:115272
|
|
increased mean platelet volume |
J:115272
|
|
increased urine protein level |
J:115272
|
|
kidney inflammation |
J:115272
|
|
premature death |
J:115272
|
|
thrombocytopenia |
J:115272
|
Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
involves: BALB/c
|
arrested B cell differentiation |
J:155473
|
Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom
B6.Cg-Rag1tm1Mom Cd160tm1Yxf
|
decreased interferon-gamma secretion |
J:222131
|
|
increased tumor growth/size |
J:222131
|
Clec2htm1.1Apma/Clec2htm1.1Apma
Rag1tm1Mom/Rag1tm1Mom
B6.Cg-Rag1tm1Mom Clec2htm1.1Apma
|
abnormal adipose tissue amount |
J:322835
|
|
abnormal kidney capillary morphology |
J:322835
|
|
abnormal renal glomerulus morphology |
J:322835
|
|
decreased body weight |
J:322835
|
|
glomerular crescent |
J:322835
|
|
glomerulosclerosis |
J:322835
|
|
increased mesangial cell number |
J:322835
|
|
kidney inflammation |
J:322835
|
|
renal glomerulus fibrosis |
J:322835
|
|
renal interstitial fibrosis |
J:322835
|
|
renal tubule atrophy |
J:322835
|
Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+
Rag1tm1Fwa/Rag1tm1Fwa
chimera involves: C57BL/6 * C57BL/6N
|
abnormal B cell physiology |
J:207033
|
|
abnormal B-1a B cell morphology |
J:207033
|
|
decreased B cell proliferation |
J:207033
|
|
decreased B-1a cell number |
J:207033
|
|
decreased IgG2b level |
J:207033
|
|
decreased IgM level |
J:207033
|
|
decreased plasma cell number |
J:207033
|
Col1a1tm1(tetO-Fos)Wag/Col1a1+
Rag1tm1Mom/Rag1tm1Mom
Tg(KRT5-rtTA)T2D6Sgkd/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
|
normal
integument phenotype |
J:201145
|
|
skin hyperplasia |
J:201145
|
|
skin lesions |
J:201145
|
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
|
abnormal T cell activation |
J:119845
|
|
increased interleukin-4 secretion |
J:119845
|
|
increased T cell proliferation |
J:119845
|
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
|
normal
immune system phenotype |
J:140448
|
|
normal
mortality/aging |
J:140448
|
|
normal
pigmentation phenotype |
J:140448
|
Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+
involves: 129S/SvEv
|
increased leukemia incidence |
J:98679
|
|
increased lymphocyte cell number |
J:98679
|
|
increased T cell derived lymphoma incidence |
J:98679
|
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
|
decreased T cell number |
J:147057
|
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
|
decreased T cell number |
J:147057
|
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Not Specified
|
normal
immune system phenotype |
J:97029
|
|
no abnormal phenotype detected |
J:97029
|
Gt(ROSA)26Sortm1(DTA)Lky/?
Il5tm1.1(icre)Lky/Il5+
Rag1tm1Mom/Rag1tm1Mom
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
abnormal immune system physiology |
J:206097
|
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-Rag1tm1Mom H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
|
abnormal response to transplant |
J:113267
|
|
normal
cardiovascular system phenotype |
J:113267
|
|
enlarged heart |
J:113267
|
|
heart inflammation |
J:113267
|
|
increased autoantibody level |
J:113267
|
|
myocarditis |
J:113267
|
|
prolonged PR interval |
J:113267
|
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
NOD.Cg-Rag1tm1Mom H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl
|
abnormal response to transplant |
J:88055
|
|
myocarditis |
J:88055
|
H2b/H2b
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
involves: 129S7/SvEvBrd * C57BL/6
|
normal
immune system phenotype |
J:19795
|
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
|
brain inflammation |
J:189816
|
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
|
brain inflammation |
J:189816
|
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
|
increased circulating glucose level |
J:111874
|
|
increased susceptibility to autoimmune diabetes |
J:111874
|
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
|
increased susceptibility to autoimmune diabetes |
J:111874
|
|
insulitis |
J:111874
|
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
|
increased susceptibility to autoimmune diabetes |
J:111874
|
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
|
decreased susceptibility to autoimmune diabetes |
J:111874
|
|
normal
digestive/alimentary phenotype |
J:111874
|
H2u/H2u
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)
|
increased susceptibility to autoimmune disorder |
J:19795
|
|
limb paralysis |
J:19795
|
Ier3tm1Mxw/Ier3tm1Mxw
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C57BL/6
|
decreased susceptibility to induced colitis |
J:194587
|
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
involves: 129S/Sv * BALB/c * C3H * C57BL/6
|
abnormal spleen germinal center morphology |
J:100072
|
|
abnormal T cell differentiation |
J:100072
|
|
increased IgE level |
J:100072
|
|
increased IgG level |
J:100072
|
Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
|
abnormal adaptive immunity |
J:140388
|
|
abnormal innate immunity |
J:140388
|
|
abnormal response to transplant |
J:140388
|
|
abnormal spleen morphology |
J:140388
|
|
abnormal thymus morphology |
J:140388
|
|
absent NK T cells |
J:140388
|
|
absent thymus cortex |
J:140388
|
|
absent thymus medulla |
J:140388
|
|
decreased macrophage cell number |
J:140388
|
|
decreased spleen B cell follicle number |
J:140388
|
|
thymus cyst |
J:140388
|
Inpp5dtm1Rkh/Inpp5dtm1Rkh
Rag1tm1(GFP)Imku/Rag1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal lymphopoiesis |
J:117320
|
Ins2Akita/Ins2+
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz
|
abnormal glucose homeostasis |
J:138005
|
|
abnormal pancreatic islet morphology |
J:138005
|
|
absent mature B cells |
J:138005
|
|
absent T cells |
J:138005
|
|
normal
homeostasis/metabolism phenotype |
J:138005
|
|
hyperglycemia |
J:138005
|
|
increased erythrocyte cell number |
J:138005
|
|
increased granulocyte number |
J:138005
|
|
increased macrophage cell number |
J:138005
|
|
increased monocyte cell number |
J:138005
|
Ins2Akita/Ins2Akita
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz
|
postnatal lethality, complete penetrance |
J:138005
|
Itktm1Ljb/Itktm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
involves: 129 * C57BL/10
|
abnormal CD4-positive T cell differentiation |
J:93606
|
|
decreased interferon-gamma secretion |
J:93606
|
|
decreased interleukin-4 secretion |
J:93606
|
|
decreased interleukin-5 secretion |
J:93606
|
|
decreased interleukin-10 secretion |
J:93606
|
Jak3tm1Ljb/Jak3tm1Ljb
Rag1tm1Mom/Rag1tm1Mom
involves: 129S4/SvJae * 129S7/SvEvBrd
|
abnormal splenic cell ratio |
J:56629
|
|
normal
immune system phenotype |
J:56629
|
Lattm1.1Mal/Lattm1.1Mal
Rag1tm1Bal/Rag1tm1Bal
involves: 129S2/SvPas * 129S4/SvJae
|
abnormal platelet dense granule physiology |
J:125744
|
|
decreased platelet aggregation |
J:125744
|
Lattm2.1Mal/Lattm2.1Mal
Rag1tm1Bal/Rag1tm1Bal
involves: 129S2/SvPas * 129S4/SvJae
|
abnormal platelet dense granule physiology |
J:125744
|
|
abnormal thrombosis |
J:125744
|
|
decreased platelet aggregation |
J:125744
|
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
|
abnormal T cell differentiation |
J:37062
|
|
decreased T cell number |
J:37062
|
Lmo2tm3Thr/Lmo2tm4Thr
Rag1tm1(cre)Thr/Rag1+
involves: 129S/SvEv
|
normal
hematopoietic system phenotype |
J:86869
|
|
normal
immune system phenotype |
J:86869
|
Man2a1tm1Jxm/Man2a1tm1Jxm
Rag1tm1Mom/Rag1tm1Mom
B6.129-Rag1tm1Mom Man2a1tm1Jxm
|
abnormal nephron morphology |
J:124348
|
|
alopecia |
J:124348
|
|
increased mesangial cell apoptosis |
J:124348
|
|
increased urine protein level |
J:124348
|
|
kidney inflammation |
J:124348
|
|
weight loss |
J:124348
|
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Rag1tm1Mom/Rag1tm1Mom
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
abnormal cytokine secretion |
J:172117
|
|
decreased body weight |
J:172117
|
|
increased circulating interleukin-1 beta level |
J:172117
|
|
increased circulating interleukin-6 level |
J:172117
|
|
increased circulating tumor necrosis factor level |
J:172117
|
|
increased inflammatory response |
J:172117
|
|
increased interferon-gamma secretion |
J:172117
|
|
increased interleukin-1 beta secretion |
J:172117
|
|
increased interleukin-2 secretion |
J:172117
|
|
increased interleukin-4 secretion |
J:172117
|
|
increased interleukin-5 secretion |
J:172117
|
|
increased interleukin-9 secretion |
J:172117
|
|
increased interleukin-10 secretion |
J:172117
|
|
increased interleukin-12 secretion |
J:172117
|
|
increased interleukin-13 secretion |
J:172117
|
|
increased interleukin-17 secretion |
J:172117
|
Mpztm1Msch/Mpz+
Rag1tm1Mom/Rag1tm1Mom
B6.129S7-Mpztm1Msch Rag1tm1Mom
|
abnormal myelin sheath morphology |
J:59319
|
|
abnormal myelination |
J:59319
|
|
abnormal nerve conduction |
J:59319
|
|
abnormal neuron morphology |
J:59319
|
|
absent CD4-positive, alpha-beta T cells |
J:59319
|
|
absent CD8-positive, alpha-beta T cells |
J:59319
|
|
increased Schwann cell number |
J:59319
|
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
|
normal
immune system phenotype |
J:205692
|
Nfil3tm1Pbro/Nfil3tm1Pbro
Rag1tm1Mom/Rag1tm1Mom
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
normal
immune system phenotype |
J:209365
|
Nlrp3tm1Hhf/Nlrp3+
Rag1tm1Mom/Rag1tm1Mom
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
|
absent B cells |
J:150054
|
|
absent T cells |
J:150054
|
|
postnatal lethality, complete penetrance |
J:150054
|
|
reddish skin |
J:150054
|
|
scaly skin |
J:150054
|
|
slow postnatal weight gain |
J:150054
|
Pdpntm2.1Mlkn/Pdpntm2.1Mlkn
Rag1tm1Mom/Rag1tm1Mom
Tg(Pdgfrb-cre)9Rha/0
involves: 129S7/SvEvBrd * C57BL/6
|
absent lymphocyte |
J:205423
|
|
normal
cardiovascular system phenotype |
J:205423
|
Plcg2Ali5/Plcg2+
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5
|
chronic inflammation |
J:97930
|
|
dermatitis |
J:97930
|
|
osteoarthritis |
J:97930
|
Pld4tm1.2Nemz/Pld4tm1.2Nemz
Rag1tm1Mom/Rag1tm1Mom
involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N
|
abnormal peritoneal macrophage morphology |
J:281205
|
|
decreased NK T cell number |
J:281205
|
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ
|
abnormal response to transplant |
J:91764
|
|
increased circulating glucose level |
J:91764
|
Pstpip2Lupo/Pstpip2Lupo
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J
|
skin inflammation |
J:125785
|
Rag1tm1(cre)Thr/?
Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi
involves: C57BL/6N
|
normal
immune system phenotype |
J:212898
|
Rag1tm1(GFP)Imku/?
Zfp335blt/Zfp335blt
involves: C57BL/6 * CBA
|
abnormal CD4-positive T cell differentiation |
J:214793
|
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * BALB/c * C57BL/6
|
absent gamma-delta T cells |
J:187400
|
|
decreased gamma-delta T cell number |
J:187400
|
|
increased gamma-delta T cell number |
J:187400
|
|
small thymus |
J:187400
|
Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/?
involves: 129S4/SvJae * C57BL/6
|
abnormal CD4-positive, alpha beta T cell morphology |
J:133645
|
|
decreased CD4-positive, alpha-beta T cell number |
J:133645
|
|
increased CD8-positive, alpha-beta T cell number |
J:133645
|
Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6
|
liver inflammation |
J:92470
|
Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
involves: 129S4/SvJae * 129S8/SvEv
|
arrested T cell differentiation |
J:113270
|
Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL
|
decreased CD4-positive, alpha-beta T cell number |
J:113270
|
Rag1tm1Fwa/Rag1tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac
|
normal
cellular phenotype |
J:170462
|
Rag1tm1Jsek/Rag1tm1Jsek
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac
|
decreased survivor rate |
J:146912
|
|
increased T cell derived lymphoma incidence |
J:146912
|
|
premature death |
J:146912
|
|
spontaneous chromosome breakage |
J:146912
|
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
involves: 129/Sv * C57BL/6 * DBA/2
|
increased T cell derived lymphoma incidence |
J:47667
|
|
premature death |
J:47667
|
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
|
increased T cell derived lymphoma incidence |
J:47667
|
|
premature death |
J:47667
|
Rag1tm1Mom/Rag1tm1Mom
Prf1tm1Sdz/Prf1tm1Sdz
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz
|
abnormal level of surface class II molecules |
J:109843
|
|
abnormal lymph node cortex morphology |
J:109843
|
|
abnormal response to transplant |
J:109843
|
|
abnormal spleen white pulp morphology |
J:109843
|
|
abnormal thymus cortex morphology |
J:109843
|
|
decreased CD4-positive, alpha-beta T cell number |
J:109843
|
|
decreased CD8-positive, alpha-beta T cell number |
J:109843
|
|
decreased immunoglobulin level |
J:109843
|
|
decreased mature B cell number |
J:109843
|
|
impaired natural killer cell mediated cytotoxicity |
J:109843
|
|
increased granulocyte number |
J:109843
|
|
increased immature B cell number |
J:109843
|
|
increased macrophage cell number |
J:109843
|
|
increased NK cell number |
J:109843
|
|
increased T cell derived lymphoma incidence |
J:109843
|
|
premature death |
J:109843
|
|
spleen hypoplasia |
J:109843
|
|
thymus hypoplasia |
J:109843
|
Rag1tm1Mom/Rag1tm1Mom
Rasa3scat/Rasa3scat
involves: 129S7/SvEvBrd * BALB/cBy
|
abnormal hematopoietic system morphology/development |
J:186485
|
|
abnormal immune system morphology |
J:186485
|
Rag1tm1Mom/Rag1tm1Mom
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J
|
abnormal osteoclast differentiation |
J:117880
|
|
decreased bone mineral density |
J:117880
|
|
increased circulating tumor necrosis factor level |
J:117880
|
|
increased inflammatory response |
J:117880
|
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
involves: 129 * C57BL/6
|
arrested T cell differentiation |
J:140121
|
|
decreased double-positive T cell number |
J:140121
|
|
increased T cell apoptosis |
J:140121
|
|
thymus hypoplasia |
J:140121
|
Rag1tm1Mom/Rag1tm1Mom
Tg(CAG-Lyn*)#Paau/0
involves: 129S7/SvEvBrd * C57BL/6
|
decreased inflammatory response |
J:151886
|
Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
involves: 129S7/SvEvBrd * C3H/He * C57BL/6
|
increased double-positive T cell number |
J:135903
|
|
increased thymocyte number |
J:135903
|
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
involves: 129/Sv * C57BL/6 * DBA/2
|
abnormal T cell receptor V(D)J recombination |
J:47667
|
|
increased T cell derived lymphoma incidence |
J:47667
|
|
premature death |
J:47667
|
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
|
increased T cell derived lymphoma incidence |
J:47667
|
|
premature death |
J:47667
|
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0
B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll
|
abnormal T cell differentiation |
J:131347
|
|
abnormal T cell subpopulation ratio |
J:131347
|
|
absent CD4-positive, alpha-beta T cells |
J:131347
|
|
increased CD8-positive, alpha-beta T cell number |
J:131347
|
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs/Dvs
|
increased susceptibility to autoimmune diabetes |
J:94192
|
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
|
decreased CD4-positive, alpha-beta T cell number |
J:111874
|
|
decreased lymphocyte cell number |
J:111874
|
|
decreased pancreatic beta cell number |
J:111874
|
|
decreased thymus weight |
J:111874
|
|
increased circulating glucose level |
J:111874
|
|
increased double-positive T cell number |
J:111874
|
|
increased susceptibility to autoimmune diabetes |
J:111874
|
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
|
rheumatoid arthritis |
J:54056
|
|
small intestinal inflammation |
J:54056
|
Rag1tm1Mom/Rag1tm1Mom
Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
abnormal T cell differentiation |
J:84536
|
Rag1tm1Mom/Rag1tm1Mom
Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
abnormal trabecular bone morphology |
J:294030
|
|
decreased osteoclast cell number |
J:294030
|
|
increased osteoblast cell number |
J:294030
|
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd * C57BL
|
dehydration |
J:141515
|
|
impaired balance |
J:141515
|
|
increased hemangiosarcoma incidence |
J:141515
|
|
increased hepatocellular carcinoma incidence |
J:141515
|
|
increased medulloblastoma incidence |
J:141515
|
|
increased pituitary adenoma incidence |
J:141515
|
|
increased sarcoma incidence |
J:141515
|
|
increased T cell derived lymphoma incidence |
J:141515
|
|
premature death |
J:141515
|
|
respiratory distress |
J:141515
|
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL
|
dehydration |
J:141515
|
|
impaired balance |
J:141515
|
|
increased medulloblastoma incidence |
J:141515
|
|
increased sarcoma incidence |
J:141515
|
|
increased stomach tumor incidence |
J:141515
|
|
increased T cell derived lymphoma incidence |
J:141515
|
|
premature death |
J:141515
|
|
respiratory distress |
J:141515
|
Rag1tm1Mom/Rag1tm1Mom
Tyrobptm1.1Viv/Tyrobptm1.1Viv
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10
|
abnormal bone remodeling |
J:129304
|
|
abnormal osteoclast physiology |
J:129304
|
|
increased bone mass |
J:129304
|
|
increased bone trabecula number |
J:129304
|
|
increased trabecular bone connectivity density |
J:129304
|
|
osteopetrosis |
J:129304
|
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6
|
abnormal tumor susceptibility |
J:138466
|
Rag1tm1Mom/Rag1tm1Mom
Vtcn1tm1Lpc/Vtcn1tm1Lpc
involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6
|
abnormal neutrophil differentiation |
J:145712
|
|
decreased susceptibility to bacterial infection |
J:145712
|
|
decreased susceptibility to bacterial infection induced morbidity/mortality |
J:145712
|
|
increased neutrophil cell number |
J:145712
|
|
increased spleen weight |
J:145712
|
Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL
|
increased cerebellar granule cell number |
J:141515
|
|
normal
neoplasm |
J:141515
|
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