Tnfsf14^tm1Kpf
Targeted Allele Detail

Summary

• Symbol: Tnfsf14^tm1Kpf
• Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:2671122
• Synonyms: LIGHT -
• Gene: Tnfsf14 Location: Chr17:57496492-57501177 bp, - strand Genetic Position: Chr17, 29.71 cM, cytoband D-E1
• Alliance: Tnfsf14^tm1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77250
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from activated splenocytes of homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:77250)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf14 Mutation: 25 strains or lines available

References

• Original: J:77250 Scheu S, et al., Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med. 2002 Jun 17;195(12):1613-24
• All: 39 reference(s)