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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(cre/ERT2)Brn
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Anton Berns
MGI ID: MGI:3764519
Synonyms: ERT2, Gt(ROSA)26Sortm2(cre/Esr1)Brn, Rosa26CreERT2, ROSA26-CreERT2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(cre/ERT2)Brn page
Germline Transmission:  Earliest citation of germline transmission: J:127226
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Gt(ROSA)26Sortm2(cre/ERT2)Brn expression driven by 1 gene
Mutation detailsThe endogenous locus was modified by insertion into the first intron of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT2 fusion gene, which encodes Cre recombinase joined to a mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Western blot analysis confirmed expression of the cre/ERT2 fusion product. (J:127226)
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm2(cre/ERT2)Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  968 strains or lines available
Original:  J:127226 Hameyer D, et al., Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol Genomics. 2007 Sep 19;31(1):32-41
All:  103 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory