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Targeted Allele Detail
Symbol: Ins2tm1Jja
Name: insulin II; targeted mutation 1, Jacques Jami
MGI ID: MGI:2181878
Synonyms: Ins2-, proins-2-, proinsulin 2-
Gene: Ins2  Location: Chr7:142232393-142233463 bp, - strand  Genetic Position: Chr7, 88.0 cM
Alliance: Ins2tm1Jja page
Severe insulitis in Ins2tm1Jja/Ins2tm1Jja mice and lack of insulitis in Ins1tm1Jja/Ins1tm1Jja mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:40377
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of the coding region was replaced by the insertion of a lacZ-neo fusion gene. The expression of lacZ was found to be under the control of the endogenous promoter via cytochemical assays. (J:40377)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ins2 Mutation:  91 strains or lines available
Original:  J:40377 Duvillie B, et al., Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5137-40
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory